Results 221 to 230 of about 10,062,834 (296)

Enhancing the effectiveness of multidisciplinary interventions to improve blood culture efficiency and optimize antimicrobial utilization. [PDF]

Front Public Health
Almaghrabi RHD, Alharbi DSS, Alqahtani KSM, Alzouman MAY, Almutairi TSJ, Alotaibi ABT, Rajab MG, Al Kuwaiti MAM, Akresh AIZ, Alaboudi NS, AlThibani NM, Alotaibi ASS, Kaabia NM, Alotaibi MZE, Alalyani SST, Alfahad WAM, Alnakhli FAAA, Alabdulsalam AAI.   +17 more
europepmc   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Analysis of purines and pyrimidines across biospecimens: influence of storage temperature and duration. [PDF]

Sci Rep
Wurth R, Turgeon C, Lacey J, Stander Z, Gavrilov D, Hall PL, Matern D, Schultz M, Tortorelli S, Oglesbee D.   +9 more
europepmc   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

DNA Extraction Optimisation for Minute Land Snails of <i>Vertigo</i> Müller, 1773 (Gastropoda: Vertiginidae): A Comparative Evaluation of Six Methods, Including a Non-Destructive Shell-Preserving Protocol. [PDF]

Ecol Evol
Jukonis B, Havelka J, Skujienė G.
europepmc   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Evaluation of the Allplex™ <i>H. pylori</i> & ClariR assay for the detection of clarithromycin-resistant <i>Helicobacter pylori</i> in gastric biopsies. [PDF]

J Med Microbiol
Ross CJP, Lock K, Ibrahim A, Hedges D, Mohamed S, Hales M, Edwards T, Jenkins C, Olonade I, Swift C.   +9 more
europepmc   +1 more source

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

Best practices for using biological data in psychological research. [PDF]

J Mood Anxiety Disord
Hawn SE, Sinnott SM, Smith AK, Bourassa K, Brick L, Hemmings S, Seedat S, Javanbakht A, Smith L, Seligowski AV, Kimbrel NA, Mehta D, Abbasi H, Wolf E.   +13 more
europepmc   +1 more source