Results 141 to 150 of about 2,385,893 (283)
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
A Double-Track Auction for Substitutes and Complements [PDF]
We propose a new t^atonnement process called a double-track auction for efficiently allocating multiple heterogeneous indivisible items in two distinct sets S1 and S2 to many buyers who view items in the same set as substitutes but items across the two ...
Ning Sun, Zaifu Yang
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FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li +7 more
wiley +1 more source
Collagen Substitutes in Oral Soft Tissue Augmentation: An In Vitro-Ex Vivo Study on Expansion and Elasticity. [PDF]
Clin Exp Dent ResMancini L +5 more
europepmc +1 more source
Complements and substitutes in multilateral assignment markets [PDF]
I prove that, in assignment markets with more than two sides, agents of different sides (or sectors) need not be complements, whereas agents of the same side need not be substitutes.
Oriol Tejada
core
FEBS Open Bio, EarlyView.This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli +2 more
wiley +1 more source
Blood Transfusion Service Board annual report 1998
, 1998 The year under review was another difficult and challenging year for the Blood Transfusion Service Board. It was also the year in which many solid foundations were laid, which will assist in redeveloping and refocusing blood transfusion services in ...
Blood Transfusion Service Board
core