Results 191 to 200 of about 4,631,334 (404)

BLOOD TRANSFUSION IN CHILDHOOD [PDF]

, 1936
D. Browne
openalex   +1 more source

Mechanisms of red blood cell transfusion‐related immunomodulation

Transfusion, 2018
Kenneth E. Remy, M. Hall, J. Cholette, N. Juffermans, K. Nicol, A. Doctor, N. Blumberg, P. Spinella, P. Norris, M. Dahmer, J. Muszynski   +10 more
semanticscholar   +1 more source

Safety, Pharmacokinetics, and Pharmacodynamics of Osivelotor for Sickle Cell Disease: First‐in‐Human Studies in Healthy Participants and Patients

Clinical Pharmacology &Therapeutics, EarlyView.
The investigational agent osivelotor, a small molecule hemoglobin (Hb) modifier in development for the treatment of sickle cell disease (SCD), acts by increasing Hb‐oxygen affinity and inhibiting the polymerization of sickle Hb. We report safety, pharmacokinetic (PK), and pharmacodynamic (PD) data from the first two phase 1 clinical trials of ...
Eleanor A. Lisbon, R. Clark Brown, Andrew Redfern, Ken Duchin, Aline Barth, Erika S. Roberts, Polo Gaputan, Kobina Dufu, Arthur Lo, Mira Patel Pochron, David R. Archer, Wai Chin, Karena Kong, Carla B. Washington, Adeyemi Adenola, Eric I. Zimmerman   +15 more
wiley   +1 more source

THE TRANSFUSION OF BLOOD [PDF]

, 1911
Arthur H. Curtis
openalex   +1 more source

Population Pharmacokinetics and Exposure–Response Analyses of Momelotinib, Its Active Metabolite (M21), and Total Active Moiety in Myelofibrosis

Clinical Pharmacology &Therapeutics, EarlyView.
Momelotinib, a Janus kinase (JAK) 1/JAK2/activin A receptor type 1 inhibitor, is approved for the treatment of myelofibrosis with anemia. These analyses characterized the population pharmacokinetics of momelotinib and its active metabolite M21 following administration of the commercial tablet formulation in patients with myelofibrosis from phase II/III
Benjamin Rich, Meenakshi Srinivasan, Yu Liu Ho, Sandra A.G. Visser, Geraldine Ferron‐Brady, Georgios Vlasakakis   +5 more
wiley   +1 more source

EXOGENOUS HEMOCHROMATOSIS RESULTING FROM BLOOD TRANSFUSIONS [PDF]

, 1948
Steven O. Schwartz, Sunoll A. Blumenthal
openalex   +1 more source

Estimation of Plasma Volume by Machine Learning to Improve the Interpretation of the Athlete Biological Passport

Drug Testing and Analysis, EarlyView.
A new machine learning model for plasma volume (PV) estimation was applied within the ABP framework. PV estimation was applied through visual displays or corrected ABP thresholds. With a favorable assessment from ABP experts, these results support further application of this model in the presence of specific confounding factors.
Bastien Krumm, Laura Lewis, Jakob Mørkeberg, Yorck Olaf Schumacher, Giuseppe d'Onofrio, Basile Moreillon, Raphael Faiss   +6 more
wiley   +1 more source

STUDIES OF BACTERIAL TRANSFUSION REACTIONS FROM REFRIGERATED BLOOD: THE PROPERTIES OF COLD-GROWING BACTERIA 1 [PDF]

, 1955
Abraham I. Braude, F. J. Carey, Jennie Siemienski   +2 more
openalex   +1 more source

Association of Prehospital Blood Product Transfusion During Medical Evacuation of Combat Casualties in Afghanistan With Acute and 30-Day Survival

Journal of the American Medical Association (JAMA), 2017
S. Shackelford, D. D. del Junco, Nicole C Powell-Dunford, E. Mazuchowski, Jeffrey T. Howard, Russ S. Kotwal, J. Gurney, F. Butler, Kirby R Gross, Z. Stockinger   +9 more
semanticscholar   +1 more source

mRNA Biomarkers in Dried Blood Spots May Improve Detection of Autologous Blood Micro‐Transfusions Using an Individualized Approach

Drug Testing and Analysis, EarlyView.
This study shows that measuring ALAS2 mRNA expression from dried blood spots (DBS) can sensitively identify autologous blood micro‐transfusions (ABMTs) ABMTs with > 95% sensitivity and specificity through individualized analysis. These results highlight ALAS2 mRNA in DBS as a promising tool to strengthen anti‐doping efforts against small‐volume ...
Andreas Breenfeldt Andersen, Jessica Almeida Oliveira, Francesco Loria, Jacob Bejder, Olivier Salamin, Tiia Kuuranne, Nikolai B. Nordsborg, Nicolas Leuenberger   +7 more
wiley   +1 more source