Results 301 to 310 of about 189,366 (324)

Controlling Release Kinetics of an Adjuvant from a Depot Improves the Efficacy of Local Immunotherapy in Metastatic Cancer

Advanced Science, EarlyView.
We show that intratumoral release of an immunotherapy—CpG —can be tuned with molecular precision by complexing it to an elastin‐like polypeptide (ELP). Injecting ELP‐CpG and an excipient ELP into tumors drives thermally‐triggered phase separation into a micro‐scale “sponge” depot that releases CpG at rates depending on the ELP composition, which ...
Joshua J. Milligan, Rachel L. Strader, Arunangshu Chakrabarty, Max Ney, Parul Sirohi, Jonathan C. Su, Anastasia K. Varanko, Yulia Shmidov, Kalina Tsolova, Cassio Mendes Fontes, Anna Finkelstein, Rohinee Mattikalli, Yun‐Xing Wang, Lixin Fan, Xinghai Li, Smita K. Nair, Ashutosh Chilkoti   +16 more
wiley   +1 more source

Targeting Neutrophil/Eosinophil Extracellular Traps by Aptamer‐Functionalized Nanosheets to Overcome Recalcitrant Inflammatory Disorders

Advanced Science, EarlyView.
In this study, C‐TAH, as multifunctional nanosheets, is developed with tannic acid and histone aptamer coverage. C‐TAH displays mild cytotoxicity, robust dsDNA and NETs/EETs binding efficiency, and potent antioxidant and antibacterial ability in vitro. C‐TAH treatment ameliorates dysregulated inflammation and restores hearing function in animal models,
Yongqiang Xiao, Xinyue Wang, Ming Liu, Xiao Fu, Nanfeng Zhang, Wenqing Yang, Junyi Ge, Yangyang Li, Duan Ma, Jing Ma, Weiping Wen, Dongdong Ren, Tianyu Zhang, Zhaoxu Tu   +13 more
wiley   +1 more source

Tuneable Hydrogel Porosity via Dynamic Tailoring of Spinodal Decomposition

Advanced Science, EarlyView.
The authors introduce a straightforward method for dynamically halting the phase separation of a gelatin methacryloyl and poly(vinyl alcohol) (GelMA‐PVA) polymer blend in the context of a biofabrication process based on dynamic interface printing (DIP).
Michael Halwes, Callum Vidler, Lilith Caballero Aguilar, Farzaneh Taromian, David R Nisbet, Melanie Stamp, Khoon S. Lim, Andrea J. O'Connor, David J. Collins   +8 more
wiley   +1 more source

Multiscale Organization of Neural Networks in a 3D Bioprinted Matrix

Advanced Science, EarlyView.
A 3D bioprint model of primary neurons has been engineered with a millimeter‐scale functional neural network, and it recapitulates in vivo transcriptomic features under both normal and disease conditions to the greatest extent. The successful integration of mature neurons and 3D bioprinting signifies a major advance in neuroscience modeling ...
Huiyu Yang, Jiangang Zhang, Yiran Li, Zihan Zhong, Wenhua Li, Haojun Luo, Yanyong Liu, Liujian Ouyang, Zhuoran Jiang, Yuning Sun, Hang Sun, Lulu Liu, Huayu Yang, Yu Wang, Nan Yang, Wenbin Ma, Yilei Mao   +16 more
wiley   +1 more source

Nasal Delivery of Engineered Exosomes via a Thermo‐Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair

Advanced Science, EarlyView.
Engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 reprogram glial cells to promote neuroprotection and neural regeneration following SCI. A chitosan‐based thermosensitive hydrogel enables sustained intranasal exosome delivery, bypassing systemic barriers and enhancing therapeutic efficacy.
Yangyang Wang, Jingsong Liu, Pengfei Li, Zhibin Peng, Yubo Zhang, Yishu Liu, Mi Li, Xuqiang Gong, Daqian Liu, Enze Xu, Hongbo Yang, Yuanliang Sun, Yan Xu, Yansong Wang   +13 more
wiley   +1 more source

Large‐Scale Production of Transfusion‐Ready Red Blood Cells From Induced Pluripotent Stem Cells

Advanced Science, EarlyView.
A scalable, dynamic culture system is developed to produce red blood cells from induced pluripotent stem cells. It achieves high yields with up to 70% enucleation, not previously shown in dynamic systems, overcoming key limitations and enabling large‐scale production.
Eszter Varga, Eelke Brandsma, Brenda E. Juarez‐Garza, Renuka P. E. Ramlal, Julien J. Karrich, Adrien Laurent, Athina Chavli, Ruthmila Paskel, Kerly Fu, Richard A. Flavell, Marieke von Lindern, Derk Amsen, Marieke E. Klijn, Emile van den Akker   +13 more
wiley   +1 more source

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Effects of sarpogrelate on blood viscosity

Microvascular Research, 2022
The objective of the present study was to evaluate the effects and safety of sarpogrelate hydrochloride (sarpogrelate) in patients with elevated blood viscosity (BV), after 12 and 24 weeks of twice (BID) or thrice (TID) daily administrations of sarpogrelate (100 mg).
Keun-Sang, Yum, Sung-Goo, Kang, Jeong-Won, Lee, Young I, Cho   +3 more
openaire   +2 more sources

Blood viscosity and aging

Archives of Gerontology and Geriatrics, 2000
The objective of this study was to evaluate the relationship of whole blood viscosity and its major determinants (plasma fibrinogen level, hematocrit, hemoglobin and blood cell count) to advancing age. A total of 249 subjects (mean age 49.9+/-21.5; range 19-102 years) were included in the study. They were divided into three groups, (A) 60 years, n, 84.
COPPOLA L, CASERTA F, DE LUCIA D, GUASTAFIERRO, Salvatore, GRASSIA A, COPPOLA A, MARFELLA, Raffaele, VARRICCHIO M.   +7 more
openaire   +3 more sources