Results 171 to 180 of about 304,931 (226)

Ginseng polysaccharides prevent mastitis through Lactobacillus murinus‐derived deoxycholic acid and TGR5 signaling

iMetaOmics, EarlyView.
Prebiotic Ginseng polysaccharides (GP) alleviate mastitis through selective enrichment of gut L. murinus, which elevates its anti‐inflammatory metabolite deoxycholic acid (DCA). Circulating DCA engages mammary epithelial TGR5 receptors, triggering the cAMP–PKA pathway to suppress NF‐κB/NLRP3‐mediated inflammation.
Zhijie Zheng, Huiying Liu, Sizhe Chen, Jianhui Gu, Sisi Cai, Xiang Liu, Raphaela I. Lau, Yao Zhang, Sunjae Lee, Xiaoyan Wang, Kewei Fan, Xiaole Yin, Hein Min Tun, Renyou Gan, Haichong Wu, Qi Su   +15 more
wiley   +1 more source

Stimuli‐responsive hydrogels: An intelligent tool for wound management

Interdisciplinary Medicine, EarlyView.
For chronic and complex wounds, this review focuses on intelligent hydrogels capable of responding to wound microenvironmental cues (e.g., pH, enzymes) or external stimuli (e.g., light, electricity). These advanced materials enable the dynamic regulation of drug release and real‐time monitoring of healing progression, thereby offering innovative ...
Debin Zheng, Meiqi Zhu, Xi Liu, Cuiping Zhang, Di Wu, Tianyu Xie, Chen Li, Pei Zhao, Wenting Chen, Xiaobing Fu, Xiaoxue Li   +10 more
wiley   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Will I Regret This? Should I Care? On Regret and Wellbeing

Journal of Applied Philosophy, EarlyView.
ABSTRACT Regret colours many areas of our lives, from the vital to the trivial. One example is in medical decision‐making, when physicians hesitate to provide procedures they think their patients will regret. For instance, physicians sometimes refuse younger women's requests for elective sterilization. Hesitating when we believe that we or someone else
Alyssa Izatt
wiley   +1 more source

Impact of the Unified Protocol on Attenuated Psychotic Symptoms, Cognitive Biases and Cognitive Insight in Patients at Ultra High Risk (UHR) for Psychosis: Secondary Results of a Pilot Randomized Controlled Trial

Journal of Clinical Psychology, EarlyView.
ABSTRACT Background and Hypothesis Ultra high risk (UHR) for psychosis can have different clinical trajectories but the remission rates are only 51.9% after 3 years of follow‐up. Deficits in metacognition are associated with severity of symptoms and poor response to treatment.
Trinidad Peláez, Raquel López‐Carrilero, Victoria Espinosa, Sol Balsells, Paolo Fusar‐Poli, Susana Ochoa, Jorge Osma   +6 more
wiley   +1 more source

The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion‐Tensor‐Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurological disorders affecting older adults, with approximately 7.2 million cases only in the United States. This number is projected to increase to 13.8 million in the United States by 2060, leading to increased expenditures for healthcare, long‐term care and hospice services. Consequently,
Valentina Zecca, Gianmauro Palombelli, Nicola Vanacore, Rossella Canese   +3 more
wiley   +1 more source

Bridging Bystander Intervention and Workplace Inclusion: The Critical Role of Perceived Fairness, Support, and Safety

Journal of Organizational Behavior, EarlyView.
ABSTRACT Bystander intervention is widely assumed to foster workplace inclusion, yet no studies have directly examined this relationship. Through abductive qualitative analysis of 53 interviews across two contrasting organisations—a consulting firm and a remote mine site—we investigate how bystander intervention relates to workplace inclusion for ...
Laura Jennings, Kun Zhao, Liam Smith, Denise Goodwin, Nicholas Faulkner   +4 more
wiley   +1 more source

Seasonal Variability of Precipitating Systems in Four Radar Domains of Northeast Brazil

International Journal of Climatology, EarlyView.
This study analyzes the climatology and evaluates how the physical aspects of precipitating systems are influenced by the dry and wet seasons in Northeast Brazil, highlighting seasonal variations in the frequency, size, intensity, and duration of these systems in the regions of Natal, Maceió, Petrolina, and Salvador.
Amanda Carolina da Silva Queiroz, Thiago Souza Biscaro   +1 more
wiley   +1 more source

Assessing Past and Future Temperature‐ and Precipitation‐Based Indicators in the Republic of Yemen

International Journal of Climatology, EarlyView.
For the first time in the literature, this work assesses the past and future climatic trends over Yemen, a highly vulnerable country for which science‐based, high‐quality information for the development of climate change adaptation plans was not available until now.
Jorge Alvar‐Beltrán, Rodrigo Manzanas, Anika Seggel, Abdulwahid Arman, Ana Casanueva, Riccardo Soldan   +5 more
wiley   +1 more source

Ch‐Ch‐Ch‐Ch‐Changes: The Impact of Supply Base Growth, Contraction, and Turnover on Firm Innovation

Journal of Operations Management, EarlyView.
ABSTRACT Modern supply chains are experiencing more disturbances due to regulatory shifts, rising sustainability standards, emerging or declining markets, and disruption to critical inputs. Some firms react by strengthening existing supplier partnerships to resist changes, while others reconfigure relationships with suppliers to embrace changes ...
Jordan M. Barker, Ellie C. Falcone, Yang Sophie Yang‐Sun, Tingting Yan   +3 more
wiley   +1 more source