Deep mutational scanning reveals EGFR mutations conferring resistance to the 4th-generation EGFR tyrosine kinase inhibitor BLU-945 [PDF]
npj Precision OncologyFourth-generation EGFR tyrosine kinase are in development to overcome common resistance mutations. We performed deep mutational scanning (DMS) of the EGFR kinase domain in the context of L858R by introducing a saturation library of ~17,000 variants into ...
Yueyang Wang +14 more
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And, 2020 A design never the same in its disparate Mediterranean forms frames a residential world capable of replacing through contemporary elements a concept of living cancelled by previous interventions.
Paolo Di Nardo
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CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction [PDF]
Nature CommunicationsCyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are the standard first-line treatment for hormone receptor-positive, HER2−negative (HR+/HER2−) metastatic breast cancer, but resistance inevitably develops.
Linjie Luo +20 more
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BLU-945, a potent and selective next-generation EGFR TKI, has antitumor activity in models of osimertinib-resistant non-small-cell lung cancer [PDF]
Therapeutic Advances in Medical OncologyIntroduction: Despite the availability of several epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), most patients with non-small-cell lung cancer (NSCLC) eventually develop resistance to these agents.
Sun Min Lim +19 more
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Studi fenomenologi: akuntansi dan perubahan sekolah menjadi Badan Layanan Umum (BLU)
Jurnal Akuntansi Aktual, 2022 This study aims to understand the meaning and awareness of actors for changing schools into Public Service Boards (BLU) and the role of accounting. Phenomenology theory is employed as theory and method in this research. The research data is the result of
Danarela Ekarani +2 more
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David superstar. Guan Xiao e le icone nell'arte
Ocula, 2020 It is enough to look around to be "touched" by an immense quantity of reproductions of works of art of every age and style. Not any image, but certain works that have become part of the collective imagination until they become true icons.
Lucia Corrain, Ottavia Mosca
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Arabiyatuna: Jurnal Bahasa Arab, 2023 The purposes of this study were to describe and analyze the strategies for improving the quality of Arabic language education in BLU State Islamic Higher Education at UIN SATU Tulungagung and UIN Maliki Malang.
Ahmad Nurcholis +5 more
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Distinct epigenetic domains separated by a CTCF bound insulator between the tandem genes, BLU and RASSF1A. [PDF]
PLoS ONE, 2010 BACKGROUND: Tumor suppressor gene (TSG) RASSF1A and candidate TSG BLU are two tandem head-to-tail genes located at 3p21.3. We hypothesized that there may be a concordance on their gene expression and promoter methylation status. If not, then there may be
Jer-Wei Chang +6 more
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Real-time terahertz imaging with a single-pixel detector [PDF]
, 2020 Terahertz (THz) radiation is poised to have an essential role in many imaging applications, from industrial inspections to medical diagnosis. However, commercialization is prevented by impractical and expensive THz instrumentation.
Blu, Thierry +3 more
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Tragedia di un artista di strada. La pratica della cancellazione da eutanasia artistica ad articidio
Ocula, 2017 This article investigates the role and meaning of practices of erasure in contemporary Italian street art culture. Taking Blu's choice of cancelling all his graffiti in the city of Bologna as a case study, I will investigate the limits and possibilities ...
Michele Martini
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