Results 121 to 130 of about 833,779 (296)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Blue energy: electricity production from salinity gradients by reverse electrodialysis

, 2009
Energie opwekken op grote schaal uit het mengen van zoet en zout water is technisch en praktisch mogelijk. Wereldwijd is de potentie van deze schone energie – ‘blauwe stroom’ – zeer groot.
Post, J.W.
core  

Fully Packaged Blue Energy Harvester by Hybridizing a Rolling Triboelectric Nanogenerator and an Electromagnetic Generator

, 2016
Ocean energy, in theory, is an enormous clean and renewable energy resource that can generate electric power much more than that required to power the entire globe without adding any pollution to the atmosphere.
Long Lin (1358919), Zhong Lin Wang (1273431), Hengyu Guo (1437850), Xia Cao (18213), Xin Wang (91924), Changsheng Wu (245222), Xu He (685343), Zhen Wen (1454947)   +7 more
core   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

The potential of blue energy for reducing emissions of CO2 and non-CO2 greenhouse gases

, 2010
Salinity gradient power (or blue energy) is a renewable energy source mentioned in the literature since the 1950s. It refers to the production of electricity by mixing of two solutions with different salt concentrations, for example river and sea water ...
Kuleszo, J., Post, J., Kroeze, C., Fekete, B.M.   +3 more
core   +1 more source

Integrated Maritime Policy for the European Union

Евразийская интеграция: экономика, право, политика, 2019
Integrated Maritime Policy for the European Union is based on the recognition that Europe's oceans and seas are interlinked, and that sea-related policies of the European States must develop in a joined-up way in order to reap the desired results.
V. S. Solodchenko, G. V. Alekseev
doaj  

Triangular Index Ratio as an Alternative Method to the Alpha Angle for Defining the Presence of Cam Morphology: A Prospective Cohort Study

Arthritis Care &Research, EarlyView.
Objective Cam morphology, which is a significant risk factor for hip osteoarthritis, is commonly quantified by the alpha angle (AA). This study aims to explore the potential of the triangular index ratio (TIR) to quantify cam morphology on anteroposterior radiographs by assessing the association between TIR‐defined cam morphology and the development of
Jinchi Tang, Fleur Boel, Michiel M. A. van Buuren, Noortje S. Riedstra, Myrthe A. van den Berg, Jos Runhaar, Sita Bierma‐Zeinstra, Rintje Agricola   +7 more
wiley   +1 more source

From Energy Blues to Green Energy: Options Before Pakistan

The Pakistan Development Review, 2014
Energy crisis in Pakistan had been brewing long before it became an important national issue with the potential to significantly affect the outcome of general elections of 2013. The looming crisis of depleting non-renewable energy sources combined with a feeble economy has lent a new urgency to the search for an energy mix which
openaire   +2 more sources