Results 151 to 160 of about 508,541 (277)

Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle

Advanced Science, EarlyView.
Using fiber photometry and genetically encoded sensors, the dynamic release patterns of four neuromodulators in the olfactory tubercle (OT)—a brain region overlapping with the olfactory cortex and ventral striatum—were systematically monitored in response to external rewards and distinct reward‐associated learning processes.
Maojun Hong, Liuting Zou, Yiqing Chen, Juan Guo, Zhixiang Xu, Tong Ma, Shuaishuai Hu, Rongfeng K. Hu   +7 more
wiley   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

The m⁵C demethylase TET1 is identified as a key regulator of scleral remodeling in myopia. [PDF]

Clin Epigenetics
Jia S, Yang L, Wei P, Yu J, Han G, Wang Y.   +5 more
europepmc   +1 more source

Effect of tear supplements on signs, symptoms and inflammatory markers in dry eye [PDF]

, 2018
Hagan, Suzanne, Martin, Eilidh, Oliver, Katherine M., Pearce, E. Ian, Simmons, Peter, Tomlinson, Alan   +5 more
core   +2 more sources

Soft and Adhesive Cardiac Patch for Electrophysiological and Contraction Measurement

Advanced Science, EarlyView.
This study developed an epicardial electronic patch with a modulus similar to that of the heart (approximately 65kPa), which can collect stable electrocardiogram signals and myocardial contractility on the surface of a dynamically beating heart. This is attributed to the hydrogen bond interaction formed between the amino and catechol groups in the ...
Wuliang Chen, Xinyu Shen, Hanning Liu, Lamei Du, Caicai Jiao, Longfei Li, Qian Wang, Qiuting Zhang, Lixue Tang, Liang Hu, Yubo Fan   +10 more
wiley   +1 more source

A hypothesis for the characteristic parafoveal toxicity observed in hydroxychloroquine retinopathy. [PDF]

Eye (Lond)
Chan M, Davies N.
europepmc   +1 more source

Shadow‐Calibrated Stereo Vision for Colorimetric Sweat Analysis

Advanced Science, EarlyView.
By establishing a mathematical model that reconstructs 3D structures through geometric features of object shadows under controlled illumination, and combining it with Convolutional Neural Network‐based 2D image analysis for volumetric calibration, this work enables highly accurate 3D morphological reconstruction.
Ting Xiao, Yuwen Yan, Miaorong Lin, Jiahui Chen, Jianxin Meng, Xiang Cui, Peng Zhang, Fengyu Li   +7 more
wiley   +1 more source

Characterization of the aqueous humor microbiome in Posner-Schlossman syndrome: an exploratory metagenomic sequencing study. [PDF]

Front Med (Lausanne)
Zhang W, Zhang K, Liao Y, Yang Z, Xia Z, Ke X, Zhang D, Chen J, Wu H, Hong Y, Wang H, Liu Z, Suo L, Zhang Y, Zhang C.   +14 more
europepmc   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source