Results 31 to 40 of about 21,794 (259)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Commercial Real Estate Valuation Using CoStar

Journal of Real Estate Practice and Education
This paper presents a structured property investment evaluation project for real estate finance courses utilizing CoStar database. Grounded in cognitive load theory, collaborative learning, and Hattie and Timperley’s feedback model, the project employs a
Margarita Kaprielyan, Angelo Boone
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Geospatial micro-estimates of slum populations in 129 Global South countries using machine learning and public data [PDF]

Earth System Science Data
Slums are a visible manifestation of poverty in Global South countries. Reliable estimation of slum populations is crucial for urban planning, humanitarian aid provision, and improving well-being.
D. Li, L. Sun, L. Sun, Y. Yu, P. Tian
doaj   +1 more source

Mapping coastal marine ecosystems of the National Park of Banc d’Arguin (PNBA) in Mauritania using Sentinel-2 imagery

International Journal of Applied Earth Observations and Geoinformation, 2021
Coastal marine ecosystems ensure fundamental hydro-ecological functions and support high levels of biodiversity, besides being an important resource for local populations.
A. Pottier, T. Catry, E. Trégarot, J.-P. Maréchal, V. Fayad, G. David, M. Sidi Cheikh, P. Failler   +7 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Not just carbon: biodiversity credits for restoration of the marine animal forests

Ecosystems and People
The ecosystems known as Marine Animal Forests (MAFs), predominantly inhabited by sessile invertebrates, represent critical biodiversity hotspots under imminent threats from human activities and climate change.
Dor Shefy, Sergio Rossi, Baruch Rinkevich   +2 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Determining the relationship between leadership practices and leadership needs in Saudi construction companies [PDF]

Journal of Engineering Management and Competitiveness, 2017
Effective leadership is demonstrated by influencing and guiding the activities of the team toward achieving its goals. This study attempts to determine the relationship between leadership practices and leadership needs in construction companies in the ...
Abdulkarim Albahali Nasser, Omran Abdelnaser   +1 more
doaj  

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source