Results 241 to 250 of about 1,184,049 (311)

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

The FEBS Journal, EarlyView.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa, Meir Solomon, Varda Lev‐Ram, Mohammad Aboraya, Anwar Dakwar, Daniela Bertinetti, Andrew Hoy, Merel O. Mol, John van Swieten, Rodrigo Maillard, Friedrich W. Herberg, Ronit Ilouz   +13 more
wiley   +1 more source

Discrepancies in the rumen microbiome, metabolome, and serum metabolome among Hu sheep, East Friesian sheep, and East Friesian × Hu crossbred sheep. [PDF]

Front Microbiol
Du R, Yan S, Yao W, Zhang H, Xue Y, Zhao Y, Cao G, Liu J, Zhang Y, Li X, Bao S, Song Y.   +11 more
europepmc   +1 more source

Cadherin‐6 controls neuronal migration during mouse neocortical development via an integrin‐mediated pathway

The FEBS Journal, EarlyView.
Neuronal migration plays essential roles in the establishment of mammalian brains, and its impairment causes severe developmental abnormalities and behavioral and cognitive deficits. Here, we report that cadherin‐6 (CDH6), an unusual cadherin molecule containing an RGD integrin‐binding motif in the first extracellular domain, controls the motility of ...
Yuki Hirota, Rikaho Saito, Takao Honda, Hitomi Sano, Mayuko Hotta, Yukiko U. Inoue, Takayoshi Inoue, Kazunori Nakajima   +7 more
wiley   +1 more source

Investigation of Anaplasma Species with Veterinary and Public Health Significance in Sheep and Goats. [PDF]

Acta Parasitol
Karatepe M, Aktaş M, Karatepe B, Özübek S.   +3 more
europepmc   +1 more source

Radio telemetry reveals extensive dispersal capabilities of reintroduced Great Capricorn beetles (Cerambyx cerdo) in oak habitats at their northern range limit

Insect Conservation and Diversity, EarlyView.
Extensive dispersal: Great Capricorn beetles dispersed up to 822 m in fragmented oak habitats. Sex‐independent movement: Dispersal distances were not significantly influenced by sex, body size or mating status. Conservation implications: Findings underscore the importance of large, connected habitats for beetle reintroductions.
Markus Franzén, Nellie Jarl, Anders Forsman, Jonas Hedin   +3 more
wiley   +1 more source

Seroprevalence of influenza A H1N1 and influenza D viruses in ruminants in Qatar. [PDF]

One Health
Zedan HT, Alziftawi T, Abdalla A, Yassine HM.   +3 more
europepmc   +1 more source

CD59, Disulphide‐Locked Human C9 and Horse C9 Inhibit Human Membrane Attack Complex Assembly by Similar Mechanisms

Immunology, EarlyView.
The membrane attack complex (MAC) is formed by the stepwise assembly of five proteins: C5b, C6, C7, C8 and C9. MAC plays a key role in driving inflammation in numerous diseases. This study compares the inhibitory mechanisms of MAC assembly by soluble CD59 (sCD59), a disulphide‐locked C9 mutant (C9lock) and horse C9 (HoC9).
Rebekah S. Cooke, Bradley A. Spicer, Richard A. Harrison, Michelle A. Dunstone, B. Paul Morgan, Wioleta M. Zelek   +5 more
wiley   +1 more source

Evaluation of Immunogenicity of an Orf Virus Vector-Based Vaccine Delivery Platform in Sheep. [PDF]

Vaccines (Basel)
Wattegedera SR, Thomson J, Coulter L, Wood A, McLean RK, Hill H, Cunnea C, Snedden K, Percival A, Palarea-Albaladejo J, Entrican G, Longbottom D, Griffiths DJ, McInnes CJ.   +13 more
europepmc   +1 more source

Epidemiology and production effects of leptospirosis in New Zealand sheep : A thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy In Veterinary Sciences at Massey University, Manawatu, New Zealand [PDF]

, 2016
Vallée, Emilie
core  

Cu‐doped magnesium phosphate supraparticles: A promising material for bone tissue regeneration

Journal of the American Ceramic Society, EarlyView.
In this study, we present antibacterial and biodegradable Cu‐doped magnesium phosphate (MgP) supraparticles prepared by spray‐drying, which offer high biocompatibility and enhanced bone regeneration potential. In contrast to conventional calcium phosphate materials, MgP exhibits superior biodegradation, which improves osteointegration.
Anika Höppel, Olivia Bahr, Regina Ebert, Christina Popp, Uwe Gbureck, Sofia Dembski   +5 more
wiley   +1 more source