Results 141 to 150 of about 1,928,900 (335)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Chelation strategy induced blue-shift for efficient deep-blue perovskite light-emitting diodes

Science Bulletin
Metal halide perovskite, regarded as a potential material for next-generation display and lighting applications, has attracted great attention [1,2]. The development of blue perovskite lightemitting diodes (PeLEDs) remains stagnant compared with their green and red counterparts in recent years [3–8].
Yu, Xia, Zhipeng, Zhang, Yu-Hang, Zhou, Yu-Han, Li, Bin, Wang, Kai-Li, Wang, Chun-Hao, Chen, Jing, Chen, Ilhan, Yavuz, Guichuan, Xing, Zhao-Kui, Wang   +10 more
openaire   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Generation of multi-watt sub-50 fs pulses in Mamyshev oscillators: influence of the central wavelength in the grating filter

High Power Laser Science and Engineering
Mamyshev oscillators (MOs) exhibit the potential for generating high average power and ultrashort pulses. Herein, we construct an MO using flexible double-cladding ytterbium-fiber with a fusion-spliced-combiner pumped scheme.
Feihong Qiao, Jinbo Wang, Xinhe Dou, Xiang Li, Bole Song, Zhiguo Lv   +5 more
doaj   +1 more source

NTDs V.2.0: “Blue Marble Health”—Neglected Tropical Disease Control and Elimination in a Shifting Health Policy Landscape

, 2013
Peter J. Hotez
openalex   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Charge-Shift Bonding in Xenon Hydrides: An NBO/NRT Investigation on HXeY···HX (Y = Cl, Br, I; X = OH, Cl, Br, I, CCH, CN) via H-Xe Blue-Shift Phenomena. [PDF]

Front Chem, 2020
Zhang G, Su Y, Zou X, Fu L, Song J, Chen D, Sun C.   +6 more
europepmc   +1 more source

Gravitational-wave imprints of Kerr--Bertotti--Robinson black holes: frequency blue-shift and waveform dephasing [PDF]

Xiangqian Li, Haopeng Yan, Xiao-Jun Yue
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Adapting to Uncertainty: Knowing Shifting Sands and Blue Infrastructure in Unpredictable Seas [PDF]

Dennis Schüpf, Jonas Hein
openalex   +1 more source