Results 151 to 160 of about 1,830,967 (340)

Lokiarchaeota archaeon schizorhodopsin-2 (LaSzR2) is an inward proton pump displaying a characteristic feature of acid-induced spectral blue-shift. [PDF]

Sci Rep, 2020
Kojima K, Yoshizawa S, Hasegawa M, Nakama M, Kurihara M, Kikukawa T, Sudo Y.   +6 more
europepmc   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Blue Exciplexes in Organic Light-Emitting Diodes: Opportunities and Challenges

Molecules
Blue exciplexes, a critical innovative component in organic light-emitting diodes (OLEDs) technology, exhibit substantial potential for enhancing device efficiency, reducing driving voltage, and simplifying structural designs.
Duxu Yan, Mengmeng Zhang, Jintao Wang, Xiaoqing Jing, Jun Sun, Yongan Zhang, Liping Yang, Ren Sheng, Ping Chen   +8 more
doaj   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Observation of Blue-Shifted Ultralong-Range Cs2 Rydberg Molecules [PDF]

, 2012
James P. Shaffer
openalex   +1 more source

Vertical motions in the quiescent prominences observed in the He I Lambda10830Angstrom line [PDF]

The observations contain two-dimensional spectral scans of a total of 17 different prominences on the solar disk from the period 3 to 9 May 1981, using the main spectrograph of the solar vacuum telescope at Sacramento Peak.
Engvold, Oddbjorn, Keil, Stephen L.
core   +1 more source

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, Volume 19, Issue 5, Page 1436-1451, May 2025.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

Generation of multi-watt sub-50 fs pulses in Mamyshev oscillators: influence of the central wavelength in the grating filter

High Power Laser Science and Engineering
Mamyshev oscillators (MOs) exhibit the potential for generating high average power and ultrashort pulses. Herein, we construct an MO using flexible double-cladding ytterbium-fiber with a fusion-spliced-combiner pumped scheme.
Feihong Qiao, Jinbo Wang, Xinhe Dou, Xiang Li, Bole Song, Zhiguo Lv   +5 more
doaj   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Very blue-shifted broad H$α$ in a low redshift Type-1.9 AGN: a disk emitter or a recoiling black hole scenario [PDF]

arXiv
In this manuscript, very blue-shifted broad H$\alpha$ with shifted velocity $\sim$2200km/s is reported in the low redshift Type-1.9 AGN SDSS J1052+1036. Blue-shifted broad emission lines may arise due to the presence of a rotating gas disk around central black hole (BH), but may also be a signature of rare phenomena such as gravitational wave recoil of
arxiv