Results 101 to 110 of about 286,241 (363)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Sharon Ann Blunt and Johnnie Wade Blunt

This oral history with siblings Sharon Ann Blunt and Johnnie Wade Blunt explores their experiences growing up during the era of school integration in Florida. The siblings discuss their experience as the family Black family to integrating in the Pinellas
Blunt, Sharon Ann, Blunt, Johnnie Wade
core  

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Blunt [PDF]

, 2021
openaire   +2 more sources

Des Edlen Herrn Henrich Blunt, Englischen Herrn und Ritters Morgenländische Reise, durch Dalmatie, Sklavonien, Thrazien und Egypten, &c. in welcher die grundfeste Des Türkischen Staats, genausichtig untersuchet wird Erstlich von ihm in Englisch verzeichne

, 2009
Preface: G.C.S.A.T.Dedication:Pagination: PP8+183PVolumes: 1Text Genre ...
Traveller-Blount, Henry-Blunt Henry, Traveller-Blount, Henry-Blount Henry, Blount, Henry-Blount Henry, Blount, Henry-Blunt Henrich, Traveller-Blount, Henry-Blunt Hendrik, Blount, Henry-Blunt Hendrik, Traveller-Blount, Henry-Blunt Henrich, Blount, Henry-Blunt Henry   +7 more
core  

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Applications of Numerical Parameters and Filtration

, 2003
This chapter discusses the applications of 3-D characterization techniques, which is the area of biotechnical surfaces. Several case studies are discussed; first case study focuses on the development of surface topography during wear of matt finish ...
Liam Blunt, Xiangqian Jiang, Blunt, Liam, Jiang, Xiangqian   +3 more
core   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Zee-en land-voyagie Van den Ridder Hendrik Blunt, Na de Levant, Gedaan in het Jaar 1634. Waar in op het naauw-keurigst verhaalt word, 't geen hem onderweegen van Venetiën door Dalmatiën, Slavoniën, Bosna, Hungaryen, Macedoniën, Thessaliën, Thraciën, Rhod

, 2009
Dedication:Content description: IndexIllustration: 1 (Maps ,Views ,)Pagination: PP2+66P+3PPVolumes: 1Text Genre:ProseIllustration: 1 (χάρτες ,τοπία ,
Traveller-Blount, Henry-Blunt Henry, Traveller-Blount, Henry-Blount Henry, Blount, Henry-Blount Henry, Blount, Henry-Blunt Henrich, Traveller-Blount, Henry-Blunt Hendrik, Blount, Henry-Blunt Hendrik, Traveller-Blount, Henry-Blunt Henrich, Blount, Henry-Blunt Henry   +7 more
core  

Injury Evaluation of Human-Robot Impacts

, 2008
Currently, large efforts are unertaken to bring robotic applications to domestic environments. Especially physical human-robot cooperation is a major concern and various design and control methodologies were developed on the way to achieve this task.
Hirzinger, Gerd, Albu-Schäffer, Alin Olimpiu, Michael Strohmayr, Haddadin, Sami, Alin Albu-Schaffer, Frommberger, Mirko, Gerd Hirzinger, Strohmayr, Michael, Sami Haddadin, Mirko Frommberger   +9 more
core   +1 more source