Results 181 to 190 of about 578,151 (361)

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

Flow in Porous Media in the Energy Transition

Engineering, 2022
Martin J. Blunt, Qingyang Lin
doaj   +1 more source

Western pediatric cervical spine study: an observational prospective Western Pediatric Surgery Research Consortium and Western Trauma Association multicenter study protocol. [PDF]

Trauma Surg Acute Care Open
Eldredge RS, Kahan AM, Padilla BE, Patwardhan UM, Presson AP, Larsen K, Lee JH, Ostlie DJ, Jensen AR, Melhado CG, Ignacio RC, Chao SD, Ravindra VM, Swendiman R, Iyer RR, Brockmeyer DL, Kelley-Quon LI, Escobar MA, Yorkgitis BK, Inaba K, Russell KW.   +20 more
europepmc   +1 more source

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Effect of Mesh Size on the Supersonic Viscous Flow Parameters around an Axisymmetric Blunt Body

, 2014
Haoui Rabah
openalex   +1 more source

A Machine Learning‐Driven Pore‐Scale Network Model Coupling Reaction Kinetics and Interparticle Transport for Catalytic Process Design

Advanced Science, EarlyView.
Designing catalytic processes in porous reactors requires resolving coupled multiscale reaction–transport phenomena. We develop a machine‐learning‐accelerated pore‐scale dual‐network model with kinetics (DNMK), which captures reaction kinetics, pore‐scale transport, and reactor‐level behavior.
Ming‐Liang Qu, Zhao‐Bin Ding, Dingyue Zhang, Sajjad Foroughi, Huanhao Chen, Zi‐Tao Yu, Jiyizhe Zhang, Lifeng Xiao, Martin J. Blunt, Xiaolei Fan, Qingyang Lin   +10 more
wiley   +1 more source

Biomechanical Investigation of Head Injuries Caused by Baseball Bat Strikes with Different Bat Sizes and Velocities: A Finite Element Simulation Study. [PDF]

Life (Basel)
Zhang H, Yang J, Guo L, Sun J, Li S, Hao W.   +5 more
europepmc   +1 more source

Blunted Cortisol Awakening Response Is Associated with External Attribution Bias Among Individuals with Personality Disorders

Bogna Bogudzińska, Julian Maciaszek, Bartłomiej Stańczykiewicz, Tomasz Bielawski, Agnieszka Dybek, Julia Alejnikowa, Tomasz Pawłowski, Błażej Misiak   +7 more
openalex   +1 more source

Bariatric Surgery Reduces Oxidative Stress by Blunting 24-h Acute Glucose Fluctuations in Type 2 Diabetic Obese Patients [PDF]

, 2009
Raffaele Marfella, Michelangela Barbieri, Roberto Ruggiero, Maria Rosaria Rizzo, Rodolfo Grella, Anna Licia Mozzillo, Ludovico Docimo, Giuseppe Paolisso   +7 more
openalex   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source