Results 241 to 250 of about 286,241 (363)

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source

Survival after severe blunt cardiac injury: Right atrial rupture. [PDF]

Trauma Case Rep
Richards J, Mendiola Pla M, Reimer J, Chang G.   +3 more
europepmc   +1 more source

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Rare and Unusual Consequences of Blunt Abdominal Trauma-The Significance of Anatomical Anomalies. [PDF]

J Clin Med
Rybicki M, Białas B, Jachymczak W, Karolczak I, Kot J, Dobrowolska K, Czyżewski BM, Czyżewska J, Paszowski K, Kłosińki KK.   +9 more
europepmc   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Delayed Manifestations of a Case of Blunt Chest Wall Trauma-Induced Pseudoaneurysm of the Mitral-Aortic Intervalvular Fibrosa: A Case Report and Literature Review. [PDF]

Clin Case Rep
Mirzaei A, Attar A, Moaref A, Amirghofran AA.   +3 more
europepmc   +1 more source

Effect of unit Reynolds number, nose bluntness, angle of attack, and roughness on transition on a 5 deg half-angle cone at Mach 8

, 1969
P. C. Stainback
openalex   +1 more source

Blunt Trauma and Diaphragm Injury in Children: An Analysis of the National Trauma Data Bank [PDF]

Sammie Lai, Spencer Wilhelm, Robert Morden, Begum Akay, Nathan M. Novotny, Anthony Stallion, Pavan Brahmamdam   +6 more
openalex   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Experimental investigation of sharp-tip microwire-based brain electrode buckling during implantation through dura and pia mater. [PDF]

Front Neurosci
Yi D, Thorson J, Kwankam N, Chen L.
europepmc   +1 more source