Results 81 to 90 of about 879,796 (267)

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Protective Effects of Imeglimin Against Oxaliplatin‐Induced Peripheral Neurotoxicity: Evidence From In Vitro and In Vivo Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Oxaliplatin is a platinum‐based anticancer agent widely used for gastrointestinal malignancies; however, it is known to cause dose‐dependent peripheral neuropathy (OIPN), a characteristic adverse effect. OIPN results in a reduced quality of life and often necessitates dose reduction or discontinuation of oxaliplatin; however, effective ...
Yusuke Koura, Kano Kinjo, Keisuke Mine, Yusuke Mori, Mami Ueda, Risa Kaneko, Yuna Kamiya, Taiga Sonoda, Haruka Mimata, Shunsuke Fujita, Takehiro Kawashiri, Daisuke Kobayashi   +11 more
wiley   +1 more source

Point‐Of‐Care Ultrasound in Emergency Departments in Australia/New Zealand: An Emergency Physician's Perspective

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 3-7, March 2025.
This brief overview of the current state of clinician performed focused ultrasound (Emergency PoCUS) by emergency practitioners in Australia/New Zealand (ANZ) has touched on its history, scope of practice both mandated and context‐dependent, complex embedding in clinical diagnostic reasoning and range of governance issues.
Robyn Brady
wiley   +1 more source

The Place of Minimally Invasive Technologies in the Treatment of Patients With Blunt Abdominal Trauma: a Systematic Review and Meta-Analysis. Secondary Control Points

Неотложная медицинская помощь
Introduction. The development of minimally invasive technologies in medicine is fast, but their role and place in surgery of blunt abdominal trauma have not yet been definitively determined.Aim of the study to compare the effectiveness of various ...
V. V. Aleksandrov, S. S. Maskin, D. S. Biriulev, V. V. Matyukhin, M. P. Ovsyannikova, A. Rachid, S. M. Sigaev   +6 more
doaj   +1 more source

Autosomal Dominant Polycystic Kidney Disease, incidental finding with trauma: Case report and review of the literature

African Journal of Urology, 2017
Introduction: Pre-existing renal lesions predispose kidneys to effects of otherwise insignificant blunt trauma, and may uncommonly present as an incidental finding in the workup of a suspected renal injury. Observation: This is a case report of a 28-year-
N.J. Gildenhuys, A. van der Merwe
doaj   +1 more source

Emergencies in Amyotrophic Lateral Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Emergencies are frequent in people living with amyotrophic lateral sclerosis (pALS), especially as the disease progresses, and can necessitate urgent evaluation and intervention. Progressive weakness in ALS inevitably increases fall risk, making discussion of fall prevention strategies integral to caring for pALS.
S. Pinar Uysal, Katherine A. Dudley, Stacey Sullivan, Kate T. Brizzi, Katherine M. Burke, Sydney Hall, Kiersten Pease, Joshua N. Goldstein, James D. Berry, Doreen T. Ho   +9 more
wiley   +1 more source

Bortezomib‐based chemotherapy in Chinese pediatric patients with relapsed/refractory acute lymphoblastic leukemia: A single‐center retrospective study

Pediatric Investigation, EarlyView.
Bortezomib‐based chemotherapy achieved an 88.9% remission rate in Chinese pediatric patients with relapsed/refractory B‐cell acute lymphoblastic leukemia, enabling 62.5% of responders to bridge to transplantation, while T‐cell acute lymphoblastic leukemia showed no response.
Xingyu Zhao, Jian Wang, Liping Que, Dunhua Zhou, Jianpei Fang, Luhong Xu   +5 more
wiley   +1 more source

A retrospective Study on Intestinal Injury from Blunt Abdominal Trauma

Introduction: Blunt abdominal trauma is the primary cause of morbidity and mortality. Suppose there are no indications of external trauma or changes in the patient's vital signs; blunt abdominal injuries might be complicated to identify at first.
Subash Chandra Bose, Muralidharan Kannaian, Bhaskara Rao Bezawada, Vinod K   +3 more
core   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

The Role of Computed Tomography in Blunt Abdominal Trauma

Journal of Nepal Medical Association, 2016
Introduction: Blunt injury trauma is regularly encountered in the emergency department. Diagnostic tools that help in optimum management of blunt abdominal trauma include; Focussed Assessment Sonography for Trauma scan, Diagnostic peritoneal lavage and ...
Om Bahadur Karki
doaj