Results 91 to 100 of about 127,984 (308)

Mitochondrial CircRNA CircMT‐RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair

open access: yesAdvanced Science, EarlyView.
CircMT‐RNR2 promotes wound healing by enhancing fibroblast proliferation, migration, contraction, and extracellular matrix (ECM) production. It sustains mitochondrial redox balance by stabilizing the antioxidant protein PRDX3, thereby reducing ROS‐induced damage. In diabetic foot ulcers, hypoxia, hyperglycemia, and reduced FGF2 and EGF expression lower
Guanglin Niu   +13 more
wiley   +1 more source

Circulating leukotriene b4 identifies respiratory complications after trauma [PDF]

open access: yes, 2012
Background. Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker ...
Auner, Birgit   +5 more
core   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

open access: yesAdvanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su   +4 more
wiley   +1 more source

Protective effect of Sildenafil on contralateral epididymal sperm concentration and motility following unilateral blunt testicular trauma in pre-pubertal male mice [PDF]

open access: yes, 2015
Background and aims: Blunt testicular trauma adversely affects fertility in later periods. The purpose of the present study was to examine the effect of sildenafil on contralateral epididymal sperm count and motility following unilateral blunt testicular
Behfar, Mehdi.   +3 more
core  

Management and outcomes of traumatic hemothorax in children [PDF]

open access: yes, 2015
Background: Adult guidelines for the management of traumatic hemothorax are well established; however, there have been no similar studies conducted in the pediatric population.
Choi, Pamela M   +3 more
core   +4 more sources

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

open access: yesAdvanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen   +11 more
wiley   +1 more source

Retrospective Autopsy Based Analysis of Nature and Prevalence of Fatal Injuries in Lahore [PDF]

open access: yes, 2020
Bacckground: Autopsy is a medical examination conducted after death to ascertain the cause of death. For Clinical autopsies, the permission of the next of kin is required.
Saghir, R. (Rabia)
core  

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

open access: yesAdvanced Science, EarlyView.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo   +10 more
wiley   +1 more source

Unexpected Complication of Blunt Trauma: Evisceration

open access: yesJournal of Pediatric Emergency and Intensive Care Medicine, 2018
Traumatic abdominal wall hernia with evisceration is an uncommon injury secondary to blunt abdominal trauma in all age groups. Bicycle handlebar injuries among children are significant causes of blunt abdominal trauma such as penetrating trauma.
Emel Ulusoy   +7 more
doaj   +1 more source

Blunt renal artery trauma: A therapeutic dilemma

open access: yesUrology Research and Practice, 2019
Blunt abdominal trauma with consequent renal artery dissection is a rare complication. Treatment is chosen on the patient's hemodynamic status, renal function and vascularization.
Umberto G. Rossi, Maurizio Cariati
doaj   +1 more source

Home - About - Disclaimer - Privacy