Results 41 to 50 of about 61,488 (297)

Exploring the Role of Stent Strut Geometry in Cellular Behavior: An In Vitro Chip Model to Understand In‐Stent Restenosis

Advanced Materials Interfaces, EarlyView.
An engineered in vitro platform mimicking stent strut cross‐sectional shapes reveals how geometry influences cell behavior. Sharp‐cornered geometries promote cell proliferation and matrix alignment, while rounded shapes reduce these effects. The findings align with clinical outcomes and suggest intracellular tension as a key driver, offering a ...
Emmie J.D. Schoutens, Juul Verbakel, Heleen M.M. van Beusekom, Jaap M.J. den Toonder, Olaf van der Sluis, Jan de Boer   +5 more
wiley   +1 more source

Non-Operative Management of Blunt Abdominal and Retroperitoneal Solid Organs Trauma, with Retroperitoneal Hemorrhage – Indications, Methodology and Necessity

Неотложная медицинская помощь, 2021
Introduction. The article is devoted to an actual problem — blunt trauma of the abdomen and organs of the retro­peritoneal space.Aim of study. Specify the indications for non­operative management of patients with blunt trauma of the solid organs of the ...
V. V. Aleksandrov, S. S. Maskin, N. K. Yermolayeva, V. V. Matyukhin   +3 more
doaj   +1 more source

Human Bone‐Derived Endothelial Cells Mediate Bone Regeneration via Distinct Expression of KIT Ligand

Advanced Science, EarlyView.
Bone‐specific endothelial cells (b‐ECs) uniquely express KITLG, which recruits c‐Kit+/CD34+ hematopoietic progenitors (HPCs) to the osteovascular niche, initiating a cascade that culminates in the osteogenic differentiation of bone marrow‐derived mesenchymal stem cells (bm‐MSCs) and subsequent ossification.
Xiang Li, Hwan D. Kim, Allen C. Luo, Liyan Gong, Yonglin Zhu, Chin Nien Lee, Xuechong Hong, Christopher L. Sudduth, Michal Ad, Young‐Hyeon An, Mihn Jeong Park, Do‐Gyoon Kim, Arin K. Greene, Bonnie L. Padwa, Nathaniel S. Hwang, Ruei‐Zeng Lin, Juan M. Melero‐Martin   +16 more
wiley   +1 more source

Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis

Advanced Science, EarlyView.
Wound infections induce gcFGF8a expression, which subsequently executes direct antimicrobial activity to suppress local infection while simultaneously activating the FGFR4‐mediated ERK/AKT‐mTOR signaling cascade, thereby upregulating HIF1α and enhancing glycolysis. These coordinated actions synergistically promote tissue repair by eliminating pathogens
Ya‐Zhen Hu, Ting Wang, Chang‐Song Wu, Jie Wang, Xue‐Qing Han, Yong‐An Zhang, Xu‐Jie Zhang   +6 more
wiley   +1 more source

Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy

Advanced Science, EarlyView.
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao, Xianping Liu, Xu Chu, Feixiang Chen, Ruicheng Shi, Zonghao Liu, Yelin Wu, Yanyan Liu, Wenbo Bu   +8 more
wiley   +1 more source

Evaluation of massive transfusion protocol practices by type of trauma at a level I trauma center

Chinese Journal of Traumatology, 2018
Purpose: To evaluate massive transfusion protocol practices by trauma type at a level I trauma center. Methods: A retrospective analysis was performed on a sample of 76 trauma patients with MTP activation between March 2010 and January 2015 at a regional
Roshan Givergis, Swapna Munnangi, Katayoun Fayaz M Fomani, Anthony Boutin, Luis Carlos Zapata, LD George Angus   +5 more
doaj  

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

A rare case of traumatic subretinal migration of crystalline lens, corroborated histologically

Indian Journal of Ophthalmology, 2017
Blunt trauma is the most common cause of posterior dislocation of the crystalline lens. We describe a rare case of subretinal migration of crystalline lens through the giant retinal tear following blunt ocular trauma.
Pritam Bawankar, Dipankar Das, Balmukund Agarwal, Kasturi Bhattacharjee, Shahinur Tayab, Panna Deka, Anshul Singh, Erani Borah, Shriya Dhar   +8 more
doaj   +1 more source

Gut Microbiota Modulates Obesity‐Associated Skeletal Deterioration Through Macrophage Aging and Grancalcin Secretion

Advanced Science, EarlyView.
Obese gut‐microbiota derived lipopolysaccharides (LPS) induce bone marrow macrophage senescence and GCA secretion via activating TLR4/NF‐κB/MAPKs pathway. Clinically, obese patients are associated with higher serum GCA levels. Mice with depletion of GCA gene show resistance to skeletal deterioration caused by obesity and LPS‐induced chronic ...
Min Huang, Mei Huang, Ling Liu, Fang Yang, Chen He, Yu‐Chen Sun, Yu‐Rui Jiao, Xiang Tang, Jing Hou, Kai‐Xuan Chen, Wen‐Zhen He, Jie Wei, Hui‐Ling Chen, Xia Li, Chao Zeng, Guang‐Hua Lei, Chang‐Jun Li   +16 more
wiley   +1 more source

BLUNT TRAUMA TO THE TRACHEA

British Journal of Anaesthesia, 1976
A 5-year-old child sustained blunt trauma to the cervical trachea. Diffuse subcutaneous emphysema of the neck and thorax developed rapidly. Anaesthesia was induced with halothane through a face-piece and the patient breathed spontaneously until the lesion has been evaluated. This course is advocated in the management of such injuries.
Y. Donchin, I.Y. Vered
openaire   +3 more sources