Results 211 to 220 of about 83,564 (303)

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

open access: yesAdvanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv   +15 more
wiley   +1 more source

ReLink: Reliable Deep Learning for Microscopic Motion Tracking

open access: yesAdvanced Science, EarlyView.
ReLink enables reliable trajectory linking in single‐particle tracking by integrating physics‐informed motion statistics with confidence‐based adaptive filtering. Across diverse simulated and experimental conditions, ReLink robustly reconstructs trajectories and preserves the fidelity of downstream analyses, enabling accurate characterization of ...
Yuan Jiang   +7 more
wiley   +1 more source

A CT Lesion Foundation Model for Non‐Invasive Assessment of Hepatocellular Carcinoma Aggressiveness and Prediction of Recurrence Risk

open access: yesAdvanced Science, EarlyView.
A computed tomography lesion foundation model, built by sequential self‐supervised pretraining on generic and hepatocellular carcinoma‐specific lesion images, non‐invasively assesses microvascular invasion and pathological grade from contrast‐enhanced CT and stratifies postoperative recurrence risk.
Wei Xia   +9 more
wiley   +1 more source

Label‐Free Super‐Resolution Imaging Using Non‐Linear Exogenous Photon Avalanche Backlight

open access: yesAdvanced Science, EarlyView.
Transmission avalanche backlight (TAB) microscopy turns a photon‐avalanching Tm3+:LiYF4 crystal into a nonlinear luminescent backlight. Weak attenuation by a transparent sample is amplified into strong emission modulation: image contrast increases with sample attenuation and avalanche nonlinearity (N), while the effective point spread function narrows ...
S. Karmegam   +5 more
wiley   +1 more source

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