Results 11 to 20 of about 29,060 (271)

BLV: lessons on vaccine development [PDF]

Retrovirology, 2019
Abstract Vaccination against retroviruses is a challenge because of their ability to stably integrate into the host genome, undergo long-term latency in a proportion of infected cells and thereby escape immune response. Since clearance of the virus is almost impossible once infection is established, the primary goal is to achieve ...
Abdala, Alejandro, Alvarez, Irene, Brossel, Hélène, Calvinho, Luis, Carignano, Hugo, Franco, Lautaro, Gazon, Hélène, Gillissen, Christelle, Hamaïdia, Malik, Hoyos, Clotilde, Jacques, Jean-Rock, Joris, Thomas, Laval, Florent, Petersen, Marcos, Porquet, Florent, Porta, Natalia, Ruiz, Vanesa, Safari, Roghaiyeh, Suárez Archilla, Guillermo, Trono, Karina, Willems, Luc   +20 more
openaire   +6 more sources

A target enrichment high throughput sequencing system for characterization of BLV whole genome sequence, integration sites, clonality and host SNP

Scientific Reports, 2021
Bovine leukemia virus (BLV) is an oncogenic retrovirus which induces malignant lymphoma termed enzootic bovine leukosis (EBL) after a long incubation period.
Nagaki Ohnuki, Tomoko Kobayashi, Misaki Matsuo, Kohei Nishikaku, Kazuya Kusama, Yasushi Torii, Yasuko Inagaki, Masatoshi Hori, Kazuhiko Imakawa, Yorifumi Satou   +9 more
doaj   +2 more sources

Recent Advances in BLV Research [PDF]

Viruses, 2015
Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species ...
Barez, Pierre-Yves, De Brogniez, Alix, Carpentier, Alexandre, Gazon, Hélène, Gillet, Nicolas, Gutiérrez, Gerónimo, Hamaïdia, Malik, Jacques, Jean-Rock, Perike, Srikanth, Neelature Sriramareddy, Sathyanarayana, Renotte, Nathalie, Staumont, Bernard, Reichert, Michał, Trono, Katrina, Willems, Luc   +14 more
openaire   +6 more sources

MicroRNAs Encoded by Bovine Leukemia Virus (BLV) Are Associated with Reduced Expression of B Cell Transcriptional Regulators in Dairy Cattle Naturally Infected with BLV

Frontiers in Veterinary Science, 2018
Bovine leukemia virus (BLV) is estimated to infect over 83% of dairy herds and over 40% of all dairy cows in the United States. While, BLV only causes leukemia in a small proportion of animals, research indicates that BLV+ cattle exhibit reduced milk ...
Meredith C. Frie, Casey J. Droscha, Ashley E. Greenlick, Paul M. Coussens   +3 more
doaj   +2 more sources

PRMT5 Is Required for Bovine Leukemia Virus Infection In Vivo and Regulates BLV Gene Expression, Syncytium Formation, and Glycosylation In Vitro

Viruses, 2020
Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis, which is the most common neoplastic disease of cattle and is closely related to human T-cell leukemia viruses.
Wlaa Assi, Tomoya Hirose, Satoshi Wada, Ryosuke Matsuura, Shin-nosuke Takeshima, Yoko Aida   +5 more
doaj   +2 more sources

Experimental infection of sheep with Bovine leukemia virus (BLV): Minimum dose of BLV-FLK cells and cell-free BLV and neutralization activity of natural antibodies

Revista Argentina de Microbiología, 2019
Bovine leukemia virus (BLV) is an important cattle pathogen that causes major economic losses worldwide, especially in dairy farms. The use of animal models provides valuable insight into the pathogenesis of viral infections. Experimental infections of sheep have been conducted using blood from BLV-infected cattle, infectious BLV molecular clones or ...
Porta, Natalia Gabriela, Alvarez, Irene, Suarez Archilla, Guillermo, Ruiz, Vanesa, Abdala, Alejandro, Trono, Karina   +5 more
openaire   +5 more sources

Estimation of bovine leukemia virus (BLV) proviral load harbored by lymphocyte subpopulations in BLV-infected cattle at the subclinical stage of enzootic bovine leucosis using BLV-CoCoMo-qPCR [PDF]

BMC Veterinary Research, 2013
AbstractBackgroundBovine leukemia virus (BLV) is associated with enzootic bovine leukosis (EBL), which is the most common neoplastic disease of cattle. BLV infection may remain clinically silent at the aleukemic (AL) stage, cause persistent lymphocytosis (PL), or, more rarely, B cell lymphoma.
Panei, Carlos Javier, Takeshima, S.-N., Omori, T., Nunoya, T., Davis, W.C., Ishizaki, H., Matoba, K., Aida, Y.   +7 more
openaire   +5 more sources

Effect of bovine leukemia virus (BLV) infection on bovine mammary epithelial cells RNA-seq transcriptome profile

PLoS ONE, 2020
Bovine leukemia virus (BLV) is a δ-retrovirus responsible for Enzootic Bovine Leukosis (EBL), a lymphoproliferative disease that affects cattle. The virus causes immune system deregulation, favoring the development of secondary infections.
Lucía Martínez Cuesta, Juan Pedro Lirón, María Victoria Nieto Farías, Guillermina Laura Dolcini, María Carolina Ceriani   +4 more
openalex   +3 more sources

Impact of BoLA-DRB3 Polymorphisms on Clonality of Bovine Leukaemia Virus-Infected Cells of Cattle With Lymphoma. [PDF]

HLA
ABSTRACT Bovine leukaemia virus (BLV) infects cattle, integrates into the host genome as a provirus, and induces a persistent infection that remains asymptomatic but can cause leukaemia/lymphoma. Most BLV‐infected cell clones are created by massive depletion, and a few of these infected cell clones expand through the mitotic cycle, leading to the onset
Fukushi N, Yamanaka MP, Matsuura R, Watanuki S, Saito S, Matsumoto Y, Fukumoto K, Hosomichi K, Wang J, Takeshima SN, Aida Y.   +10 more
europepmc   +2 more sources

Oncogenic Viruses and Breast Cancer: Mouse Mammary Tumor Virus (MMTV), Bovine Leukemia Virus (BLV), Human Papilloma Virus (HPV), and Epstein–Barr Virus (EBV) [PDF]

Frontiers in Oncology, 2018
Background Although the risk factors for breast cancer are well established, namely female gender, early menarche and late menopause plus the protective influence of early pregnancy, the underlying causes of breast cancer remain unknown.
James S. Lawson, Brian Salmons, Wendy K. Glenn   +2 more
openalex   +2 more sources