Results 61 to 70 of about 649 (195)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

CONEXÕES POLÍTICAS NAS MAIORES COMPANHIAS LISTADAS NA BM&FBOVESPA

open access: yesREAd
RESUMO As conexões políticas podem ser caracterizadas como relações entre empresas e políticos, em que as empresas procuram obter vantagens e os políticos geralmente buscam financiamento de campanha.
Bruno Goes Pinheiro   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

THE USE OF DERIVATIVES IN THE INTERIMEDIARY FINANCIAL INSTITUTIONS LISTED ON BM & FBOVESPA

open access: yes, 2014
O presente trabalho teve como objetivo identificar variáveis que influenciam o uso de instrumentos financeiros derivativos pelas instituições intermediárias financeiras do Brasil listadas na BM&FBOVESPA, bem como identificar para qual finalidade estas instituições utilizam os instrumentos financeiros derivativos no período de 2006 a 2011.
Marques, Tatiane de Oliveira   +1 more
openaire   +1 more source

Impact of the Issuance of ADRs on the Return of Shares of Brazilian Companies Listed on BM & FBovespa

open access: yesRevista Inovação, Projetos e Tecnologias - IPTEC , 2017
Nas últimas décadas, houve uma intensificação do processo de integração dos mercados de capitais no mundo, que gerou impactos profundos nas estratégias empresariais e facilitou o acesso ao capital internacional (Bell & Rasheed, 2016). Um dos instrumentos que está à disposição das empresas brasileiras e que visa facilitar a obtenção de recursos dos ...
Kuronuma, Cleiton Ricardo   +2 more
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Accounting choices in Brazil: identifying the characteristics of publicly traded companies that opted to maintain versus derecognise deferred assets

open access: yesRevista Contabilidade & Finanças, 2012
The issuance of Brazilian Law 11.638/2007 is a critical step in the convergence of the Brazilian Generally Accepted Accounting Principles (GAAPs) towards International Financial Reporting Standards.
Fernando Drago Lorencini   +1 more
doaj   +1 more source

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