Results 91 to 100 of about 1,869,874 (388)

Plasma microRNA Signature as Predictive Marker of Clinical Response to Therapy During Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite the availability of effective therapies for Multiple Sclerosis (MS), the unpredictable nature of disease progression and the variability in individual treatment outcomes call for reliable biomarkers. This pilot study aims to investigate the potential of plasma circulating microRNAs (miRNAs) as predictive biomarkers for ...
Fortunata Carbone, Alessandra Colamatteo, Teresa Micillo, Gianmarco Abbadessa, Silvia Garavelli, Clorinda Fusco, Claudia Russo, Francesco Perna, Federica Garziano, Claudia La Rocca, Maria Mottola, Giorgia Teresa Maniscalco, Simona Bonavita, Antonio Luca Spiezia, Alessia Castiello, Roberta Lanzillo, Vincenzo Brescia Morra, Claudio Procaccini, Paola de Candia, Giuseppe Matarese   +19 more
wiley   +1 more source

The association between BMI and mortality using offspring BMI as an indicator of own BMI: large intergenerational mortality study [PDF]

BMJ, 2009
To obtain valid estimates of the association between body mass index (BMI) and mortality by using offspring BMI as an instrumental variable for own BMI.Cohort study based on record linkage, with 50 years of follow-up for mortality. Associations of offspring BMI with all cause and cause specific maternal and paternal mortality were estimated as hazard ...
Debbie A Lawlor, Finn Rasmussen, Jonathan A C Sterne, Abigail Fraser, George Davey Smith, Per Tynelius   +5 more
openaire   +3 more sources

Variability and reproducibility of multi-echo T2 relaxometry: Insights from multi-site, multi-session and multi-subject MRI acquisitions

Frontiers in Radiology, 2022
Quantitative magnetic resonance imaging (qMRI) can increase the specificity and sensitivity of conventional weighted MRI to underlying pathology by comparing meaningful physical or chemical parameters, measured in physical units, with normative values ...
Elda Fischi-Gomez, Elda Fischi-Gomez, Gabriel Girard, Gabriel Girard, Gabriel Girard, Philipp J. Koch, Philipp J. Koch, Philipp J. Koch, Philipp J. Koch, Thomas Yu, Thomas Yu, Marco Pizzolato, Marco Pizzolato, Julia Brügger, Julia Brügger, Gian Franco Piredda, Gian Franco Piredda, Gian Franco Piredda, Tom Hilbert, Tom Hilbert, Tom Hilbert, Andéol G. Cadic-Melchior, Andéol G. Cadic-Melchior, Elena Beanato, Elena Beanato, Chang-Hyun Park, Chang-Hyun Park, Takuya Morishita, Takuya Morishita, Maximilian J. Wessel, Maximilian J. Wessel, Maximilian J. Wessel, Simona Schiavi, Simona Schiavi, Alessandro Daducci, Tobias Kober, Tobias Kober, Tobias Kober, Erick J. Canales-Rodríguez, Friedhelm C. Hummel, Friedhelm C. Hummel, Friedhelm C. Hummel, Jean-Philippe Thiran, Jean-Philippe Thiran, Jean-Philippe Thiran   +44 more
doaj   +1 more source

Changes in BMI, Duration of Overweight and Obesity, and Glucose Metabolism: 45 Years of Follow-up of a Birth Cohort [PDF]

, 2011
OBJECTIVE: Long-term implications of childhood obesity and BMI change over the life course for risk of type 2 diabetes remain uncertain. The objective was to establish whether there are effects on adult glucose metabolism of 1) sensitive periods of BMI ...
Barr, Carlsson, Chris Power, Claudia Thomas, Forsén, Harlow, Hyppönen, Vanhala, Wannamethee   +8 more
core   +1 more source

Placebo Effect Sizes in Clinical Trials of Knee Osteoarthritis Using Intra‐Articular Injections of Biologic Agents

Arthritis Care &Research, EarlyView.
Objective Patients with knee osteoarthritis rely on symptomatic treatments, in which up to 75% of the pain reduction can be attributed to the placebo effect. This effect may vary based on treatment type (eg, biologics vs nonbiologic injection) and route of administration (eg, intra‐articular vs topical vs oral).
Johanna M. Borst, Severin Ruoss, Ian Palmer, Trevor Smith, Kenneth Kalunian, Samuel R. Ward   +5 more
wiley   +1 more source

Factors Associated With Tracking of BMI: A Meta‐Regression Analysis on BMI Tracking* [PDF]

Obesity, 2011
Stable tracking of body composition is a prerequisite for the long‐term effect of preventive measures against obesity and its harmful effects. As BMI tracking estimates reported by individual studies vary considerably, we performed a meta‐regression analysis to provide a summary estimate and to assess determinants of BMI tracking. Using the Medline and
Otmar Bayer, André Michael Toschke, Rüdiger von Kries, Helia Krüger   +3 more
openaire   +3 more sources

Increased circulating ANG II and TNF-α represents important risk factors in obese Saudi adults with hypertension irrespective of diabetic status and BMI [PDF]

, 2012
Central adiposity is a significant determinant of obesity-related hypertension risk, which may arise due to the pathogenic inflammatory nature of the abdominal fat depot.
A Berrington de Gonzalez, A Harte, A Taube, AG Bertoni, Aimin Xu, Alison L. Harte, Amany O. Mohamed, AV Chobanian, B Chamarthi, BL Goodwin, BM Celoria, BM Cheung, C Asferg, C Asferg, C Savoia, D Gurantz, D Kalra, D Ma, ES Androulakis, F Galletti, F Galletti, G Mancia, H Itani, H Zhang, Hossam M. Draz, J Feber, J Liu, JD Fowler, JE Hall, JM do Carmo, JV Patel, K Ohashi, KF Adams, Khalid M. Alkharfy, L Alhyas, LE Bautista, Lotfi S. Bindahman, M Adamczak, M Carlyle, M Hernandez-Presa, M Pruijm, M Tohidi, M Vlasova, MA Al-Homrany, Majed S. Alokail, MY Baden, N Al-Daghri, Nasser M. Al-Daghri, NM Al-Daghri, NS Kalupahana, Omar S. Al-Attas, Philip G. McTernan, R Fogari, R Summer, RT Sabo, S Sriramula, S Yasue, Sobhy Yakout, T Wago, TA Kotchen, Tahia H. Saleem, X Gao, Y Deng, Y Takeshita   +63 more
core   +5 more sources

Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index [PDF]

, 2011
Cigarette smoking is associated with lower body mass index (BMI), and a commonly cited reason for unwillingness to quit smoking is a concern about weight gain.
Davey Smith, G, Ebrahim, S, Frayling, TM, Freathy, RM, Hattersley, AT, Hill, A, Hingorani, AD, Holst, C, Jefferis, BJ, Johnson, PC, Kazeem, GR, Kring, SI, Lawlor, DA, Mooser, V, Morris, RW, Munafò, M, Padmanabhan, S, Paternoster, L, Preisig, M, Ring, SM, Sattar, N, Sørensen, TI, Tozzi, F, Upton, MN, Vollenweider, P, Waeber, G, Watt, G, Whincup, PH   +27 more
core   +6 more sources

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

BMI peak in infancy as a predictor for later BMI in the Uppsala Family Study [PDF]

International Journal of Obesity, 2009
The development of obesity through childhood, often characterized by using body mass index (BMI), has received much recent interest because of the rapidly increasing levels of obesity worldwide. However, the extent to which the BMI trajectory in the first year of life (the BMI 'peak' in particular) is associated with BMI in later childhood has received
Richard J. Silverwood, Tim J Cole, B L De Stavola, David A. Leon   +3 more
openaire   +4 more sources