Results 201 to 210 of about 2,061,437 (333)

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Recommendations of an international Delphi study group for total knee arthroplasty in obese patients. [PDF]

Arch Orthop Trauma Surg
Rajgopal A, Palanisami DR, Annapareddy A, Khan M, Easwaran R, Shyam A, Sanghavi S, Sancheti P.   +7 more
europepmc   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4‐VCAM1 Signaling

Advanced Science, EarlyView.
We identified the endothelial RAP2A as a regulator of inflammatory endothelial activation in experimental lung fibrosis and suggest that targeting RAP2A‐mediated signaling may represent a potential strategy to modulate endothelial–immune crosstalk during fibrotic lung injury.
Xiaolan Zheng, Peng Yue, Kaiyu Zhou, Guidong Gong, Yue Zhang, Sha Lin, Xu Liu, Yanjiang Zheng, Siyuan Jing, Junling Guo, Yan Qi, Bi‐Sen Ding, Yimin Hua, Yifei Li   +13 more
wiley   +1 more source

Dissecting the Genetic Basis of Low Back Pain Independent of BMI Through Genomic Structural Equation Modeling. [PDF]

J Pain Res
Huo L, Tan L, Wang F, Sun J, Niu Y, Jiang Y, Wu M, Shi J, Hao Y, Wang J, Huang S, Chen Z.   +11 more
europepmc   +1 more source

Erratum: What is the best measure of adiposity change in growing children: BMI, BMI %, BMI z-score or BMI centile? [PDF]

European Journal of Clinical Nutrition, 2005
T J Cole, M S Faith, A Pietrobelli, M Heo   +3 more
openaire   +1 more source

Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface

Advanced Science, EarlyView.
Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley   +1 more source

Comment on: “GLM7 – A Novel Composite Glycolipid Index Derived from Routine Health Indicators for Enhanced Diagnosis and Prediction of Multimorbidity”

Advanced Science, EarlyView.
ABSTRACT The recent study by Wang et al. introduces GLM7, a novel composite index integrating routine health indicators to enhance the diagnosis and prediction of multimorbidity. The study provides compelling evidence for the utility of cost‐effective biomarkers in large‐scale health screening.
Yiquan Wang, Tin‐Yeh Huang
wiley   +2 more sources

Depression Risk in Type 1 Versus Type 2 Diabetes: Cross-Sectional Analysis of Body Mass Index (BMI) in a Nationally Diverse Cohort. [PDF]

Endocrinol Diabetes Metab
Cruz-Vespa N, Thomas ML, McCarthy MJ, Meruelo AD.   +3 more
europepmc   +1 more source

Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells.

Cancer Research, 2006
Suling Liu, G. Dontu, I. Mantle, Shivani H. Patel, N. Ahn, Kyle W. Jackson, Prerna Suri, M. Wicha   +7 more
semanticscholar   +1 more source