DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li +25 more
wiley +1 more source
Drug-eluting stents versus bare-metal stents in the treatment of drug-refractory intracranial atherosclerotic disease: a retrospective single-center comparison. [PDF]
von Gottberg P +6 more
europepmc +1 more source
Evaluating the Utilities of Foundation Models in Single‐Cell Data Analysis
This study delivers the first systematic, task‐level evaluation of single‐cell foundation models across eight core analytical tasks. By benchmarking 10 leading models with the scEval framework, it reveals where foundation models truly add value, where task‐specific methods still dominate, and provides concrete, reproducible guidelines to steer the next
Tianyu Liu +4 more
wiley +1 more source
Mechanism of paraventricular nucleus H<sub>2</sub>S on PERK/TXNIP/NLRP3 pathway in male spontaneously hypertensive rats. [PDF]
Liang YF +15 more
europepmc +1 more source
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao +11 more
wiley +1 more source
Real-world evidence of measurable residual disease assessment in multiple myeloma. [PDF]
Cedena MT +22 more
europepmc +1 more source
In Situ Characterisation of Hydrogels via Dynamic Interface Printing
ABSTRACT Hydrogels have become pivotal materials for tissue engineering, robotics, biomedical devices, and sensing applications due to their diverse material compositions and tunable mechanical properties. While significant effort has focused on developing novel manufacturing approaches such as extrusion bioprinting and light‐based fabrication methods,
Callum Vidler +2 more
wiley +1 more source
Psychosocial impact of chronic oral mucosal pain disorders: Associations with oral health related quality of life, anxiety, and depression. [PDF]
Jidiya N +8 more
europepmc +1 more source

