Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Managing and motivating academic advisory boards in animal health for high performance
Frontiers in EducationIntroductionAcademic leaders and faculty in professional academic programs often gather input from practitioners to test the relevance of academic curricula.
A. Paige Adams +2 more
doaj +1 more source
Boards of Directors: Assessing Their Functioning and Validation of a Multi-Dimensional Measure. [PDF]
Front Psychol, 2018 Asahak S +3 more
europepmc +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Regulation and the Evolution of Corporate Boards: Monitoring, Advising or Window Dressing? [PDF]
It is generally agreed that boards are endogenously determined institutions that serve both an oversight and advisory role in a firm. While oversight role of boards has been extensively studied relatively few studies have examined the advisory role of ...
Michael Sykuta, Eric Helland
core
Gender Diversity on Boards of Directors and Remuneration Committees: The Influence on Listed Companies in Spain. [PDF]
Front Psychol, 2018 García-Izquierdo AL +2 more
europepmc +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
A systematic approach to develop a core set of parameters for boards of directors to govern quality of care in the ICU. [PDF]
Int J Qual Health Care, 2018 Oerlemans AJM +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
The use of patient feedback by hospital boards of directors: a qualitative study of two NHS hospitals in England. [PDF]
BMJ Qual Saf, 2018 Lee R, Baeza JI, Fulop NJ.
europepmc +1 more source