Results 221 to 230 of about 77,301 (312)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Evaluation of Biochar and Iron as Alternative Materials to Improve Performance of Septic Systems-Part 1. Material Selection and Batch Tests. [PDF]

Water Environ Res
Chen CY, Heger S, Arrington DA, Hu B.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Canadian certification exam pass rates are impacted by genetic counseling program location: A review of Canadian Board of Genetic Counselling data from 2007 to 2025. [PDF]

J Genet Couns
Krutish A, Vanneste R, Canadian Board of Genetic Counselling.   +2 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Shrinking the Aeration Footprint: Innovative Approaches to Nitrogen Removal in MBR Systems. [PDF]

Water Environ Res
Klein A, Cavanaugh S, Morris L, Oi Y, Kuge H, Kelly R.   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Phytoremediation of Wastewater From Oil Well Drilling: Potential of Different Plant Species. [PDF]

Water Environ Res
Souza TO, Mendes TAO, Monteiro LCP, Watthier Júnior LE, Marques DDS, Borges AC.   +5 more
europepmc   +1 more source

Development and testing of a novel compact system for municipal wastewater treatment and irrigation using advanced technologies. [PDF]

Sci Rep
El-Aassar AM, Isawi H, Ali MEA, Shawky HA, Mito MT, Oterkus S, Oterkus E.   +6 more
europepmc   +1 more source

Extended Environmental Multimedia Modeling System (EEMMS) with Analytic Hierarchy Process for Dual Evaluation of Energy Consumption and Pollutants in Solid Waste. [PDF]

Toxics
Yuan J, Wang H, Chen M.
europepmc   +1 more source