Results 91 to 100 of about 217,363 (305)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Haptic vision, footwork, place-making: A peripatetic phenomenology of the mobile phone pedestrian [PDF]

, 2009
In this paper we aim to develop a post-phenomenology of walking through an analysis of the relation between pedestrian mobility and the use of mobile devices, and then apply this analysis to users of third and fourth generation location-aware touch ...
Richardson, I., Wilken, R.
core   +1 more source

A Trip to the Moon: Personalized Animated Movies for Self-reflection

, 2018
Self-tracking physiological and psychological data poses the challenge of presentation and interpretation. Insightful narratives for self-tracking data can motivate the user towards constructive self-reflection.
Bentley Todd, Braun Virginia, Freytag Gustav, Kihlstrom John F, Lancaster Kurt, Lancaster Kurt, Van Breemen AJN   +6 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

The facilitative role of listener’s pointing gestures in collaborative tasks

Frontiers in Communication
We investigated the role of listener-produced pointing gestures in a collaborative sticker localisation task. While previous research has emphasised the communicative value of speaker gestures, few experimental studies have examined how listeners ...
Kazuki Sekine, Kotaro Kanemaru, Keisuke Kadota   +2 more
doaj   +1 more source

‘It stays with you’: multiple evocative representations of dance and future possibilities for studies in sport and physical cultures [PDF]

, 2017
This article considers the integration of arts-based representations via poetic narratives together with artistic representation on dancing embodiment so as to continue an engagement with debates regarding multiple forms/representations.
Barone T., Chenail R., Crossley N., Douglas K., Goffman E., Hussey T., Leavy P., Leavy P., Leder D., Margalit A., Martell L., Merleau-Ponty M., Merleau-Ponty M., Meyerhoff E., Mountz A., Pelias R.J., Phoenix C., Pink S., Sparkes A.C.   +18 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Embodied engagement: fostering caring thinking in a multimodal singing-based learning environment for refugee children

Frontiers in Psychology
Various initiatives have implemented music programs aimed at fostering refugee children’s resilience and flourishing. However, there is a lack of studies addressing the design of these educational settings with respect to the crucial role of embodiment ...
Mahsa Mohammadhosseini, Silke Schmid
doaj   +1 more source

Medically unexplained symptoms and attachment theory: The BodyMind Approach [PDF]

, 2019
© 2019 Payne and Brooks. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright
Aamland, Abbass, Adshead, Allen, Arnold, Bar-Tal, Barsky, Bartholomew, Bartholomew, Bentzen, Bowlby, Bowlby, Burton, Ciechanowski, den Boeft, Dirkzwager, Edwards, Elbers, Gask, Giuseppe, Grossman, Henningsen, Hofmann, Holmes, Holmes, Holmes, Katon, Kolb, Kossak, Kroenke, Lambert, Levine, Lowe, Main, Malhi, Maslow, Munsell, Murphy, Noyes, Ogden, Panfile, Parrott, Payne, Payne, Payne, Payne, Payne, Payne, Payne, Payne, Payne, Payne, Payne, Payne, Porges, Porges, Raine, Rogers, Rosmalen, Sanders, Sansone, Schachner, Schröder, Segal, Selders, Smith, Smith, Sochos, Spertus, Stalker, Steinbrecher, Stuart, Taylor, Taylor, van der Kolk, van Ravesteijn, Verhaak, Waldinger, Waller, Wallin, White, Yoshihara, Zonneveld   +82 more
core   +3 more sources

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source