Results 161 to 170 of about 875,626 (269)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Neonatal steroid exposure and body composition in preterm infants at discharge. [PDF]

Pediatr Res
Kraemer MK, Johnson TJ, Bell KA, Mulcahy DC, Cerwinske LA, Patra K, Appelhans BM, David J, Belfort MB, Diep QM, Patel AL.   +10 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Sexual Dimorphism in the Relationship between Body Composition and Insulin Resistance in Older Adults. [PDF]

Curr Dev Nutr
Zhang D, Devarakonda SLS, Roberts RA, Greenway FL, Rebello CJ.   +4 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Frailty and Cardiovascular Events as Determined by Body Composition: A Systematic Review. [PDF]

Chronic Dis Transl Med
Oberoi I, Tariq S, Arak K, Al-Haffar MAA, Thet K, Abdelhafiz AH.   +5 more
europepmc   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

Cardiorespiratory fitness in working adults undergoing rehabilitation: the role of lifestyle and body composition- a cross-sectional study. [PDF]

Front Physiol
Chróścielewska N, Chomiuk T, Pałasz D, Laprus-Abramska K, Mamcarz A, Śliż D.   +5 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

CT-defined body composition is associated with postoperative burst abdomen in patients undergoing laparotomy. [PDF]

BMC Surg
Meyer HJ, Romeo D, Dermendzhiev T, Stelzner S, Scheuermann U, Denecke T, Niebisch S, Mehdorn M.   +7 more
europepmc   +1 more source