Results 121 to 130 of about 849,385 (303)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Aging and Health ResearchBackground: Imbalances in Traditional Chinese Medicine (TCM) constitution types may contribute to disease onset. Currently, comprehensive research on the distribution of TCM constitution types in VCIND (Vascular Cognitive Impairment No Dementia) is ...
Li-qi Hu +12 more
doaj +1 more source
Association of traditional Chinese medicine body constitution and cold syndrome with leukocyte mitochondrial functions: An observational study. [PDF]
Medicine (Baltimore), 2023 Ma G +10 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Physiological fingerprint of urine formation based on Prakriti (Body Constitution)
Journal of Research in Traditional MedicineBackground: Ayurveda, a traditional Indian medicine system, emphasises Prakriti (body constitution) for personalised healthcare. This concept suggests that an individual's innate constitution, determined by the predominance of three Dosha (Vata ...
Ashwini Basavraj Limbane +2 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Revista Vasca de Administración Pública, 2014 This work sets forth the critical thoughts of the Abate Sièyes regarding the need to set up a body for the protection of the Constitution. Sièyes ¿the intelectual author of the distinction between constituent power and constituted power, and one of the ...
Javier Tajadura Tejada
doaj +1 more source
Decision Tree-Based Body Constitution Diagnosis System for Traditional Chinese Medicine. [PDF]
Evid Based Complement Alternat Med, 2022 Yang CC +6 more
europepmc +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
The Relationships between Leptin, Genotype, and Chinese Medicine Body Constitution for Obesity. [PDF]
Evid Based Complement Alternat Med, 2021 Hou HI +6 more
europepmc +1 more source