Results 121 to 130 of about 847,290 (339)

Annotated Constitution of the State of Rhode Island and Providence Plantations [PDF]

open access: yes, 1988
The convention staff has here prepared an annotated version of the new Constitution which compares the new document with the 1843 Constitution, noting the similarities and differences and providing some commentary on those sections that have been added ...

core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

Guarding the Guardians? Towards an Independent, Accountable and Diverse Senior Judiciary [PDF]

open access: yes, 2012
At the heart of what Vernon Bogdanor has described as the ‘The New British Constitution’ has been the rise in the political significance of the judiciary.
Paterson, Alan, Paterson, Chris
core  

TREX1, a predator for treating MSI‐H tumors?

open access: yesMolecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya   +2 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

A Review of the Possibility of Application for Concrete Norm Control by the Turkish Football Federation Arbitration Board

open access: yesİstanbul Hukuk Mecmuası
Arbitration, as an alternative dispute resolution method, is becoming more popular for resolving sports disputes and is also rising in Turkish law. Under the Constitution of the Republic of Turkey (the Constitution), objections to sports federations ...
Dilara Yüzer Eltimur   +1 more
doaj   +1 more source

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