Results 121 to 130 of about 68,840 (288)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Student body constitution

The Constitution of the Student Body of Texas Christian ...
Texas Christian University
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Association of thermal perceptions, metabolic rate, clothing, and local skin temperature in people with cold constitution in air-conditioned office environments

Journal of Physiological Anthropology
Cold constitution refers to a phenomenon in which individuals have a higher sensitivity to cold and feel colder than others. This research aimed to examine the associations of morphological characteristics, personal factors, thermal perceptions, and ...
Biplob Kanti Biswas, Koichi Ishii, Yu Watanabe, Jiating Li, Yumiko Tan, Ayano Dempoya, So Takeuchi, Sang-il Lee, Takuji Iwamura, Shingo Konoshita, Hitoshi Wakabayashi   +10 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

A Review of the Possibility of Application for Concrete Norm Control by the Turkish Football Federation Arbitration Board

İstanbul Hukuk Mecmuası
Arbitration, as an alternative dispute resolution method, is becoming more popular for resolving sports disputes and is also rising in Turkish law. Under the Constitution of the Republic of Turkey (the Constitution), objections to sports federations ...
Dilara Yüzer Eltimur, İbrahim Doğan Takavut   +1 more
doaj   +1 more source

Associations between traditional Chinese medicine body constitution and obesity risk among US adults. [PDF]

Longhua Chin Med, 2023
Zhu X, Yin X, Deng X, Shubin YE, Murff HJ, Ness RM, Yu C, Shrubsole MJ, Dai Q.   +8 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Traditional Chinese medicine constitution types and cognitive function in patients with vascular cognitive impairment no dementia (VCIND)

Aging and Health Research
Background: Imbalances in Traditional Chinese Medicine (TCM) constitution types may contribute to disease onset. Currently, comprehensive research on the distribution of TCM constitution types in VCIND (Vascular Cognitive Impairment No Dementia) is ...
Li-qi Hu, Jia-Zhen Tong, Li-li Zhou, Yuan-yuan Jia, An-Wen Huang, Da He, Wei-Feng Hong, Xu-Jie Zhuang, Xin-Ming Wu, Yang-Hui Zhou, Ming-wang Wang, Li-Li Gao, Min Lin   +12 more
doaj   +1 more source