Results 131 to 140 of about 8,496,000 (299)

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Resting metabolic rate, body-fat distribution, and visceral fat in obese women

, 1992
Resting metabolic rate (RMR) was evaluated in 27 obese women aged 16-49 y [body mass index (in kg/m2) 27-51] by indirect calorimetry. Visceral and subcutaneous adipose tissue areas, body fat, and fat-free mass (FFM) were measured by a single scan with ...
Zamboni, M, O Bosello, F Armellini, Bosello, O, Armellini, F, Robbi, R, T Todesco, S Castelli, M Zamboni, Castelli, S, Todesco, T, R Robbi   +11 more
core   +1 more source

Fat distribution, inflammatory mechanisms, and cardiovascular disease risk: mediation analysis based on the Framingham risk score

BMC Cardiovascular Disorders
Objective To examine the association between fat distribution and 10-year cardiovascular disease (CVD) risk, and to evaluate the mediating roles of inflammatory markers in this relationship.
Zhuangzhuang Chen, Jun Li, Hao Rao, Jia Zhang, Zhili Xiao, Wei Sun, Mingzhong Xiao   +6 more
doaj   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Magnetic resonance imaging of total body fat

, 1998
In this study we assessed different magnetic resonance imaging (MRI) scanning regimes and examined some of the assumptions commonly made for measuring body fat content by MRI.
Brynes, A.E., Hajnal, J.V., Thomas, E.L., Frost, G.S., Goldstone, A.P., Saeed, N., Bell, J.D.   +6 more
core  

Clinical Assessment of Obesity Beyond Body Mass Index: Adiposity Evaluation, Body-Composition Phenotyping and Disease Staging: A Narrative Review

Diagnostics
Obesity is usually classified or assessed using the body mass index (BMI), mainly because BMI is simple and easy to apply. Its simplicity is also its main weakness. BMI does not measure fat mass, fat-free mass, or fat distribution.
Ion-Vladut Udroiu, Alin Albai, Sandra Lazar, Adina Braha, Laura Gaita, Bogdan Timar, Alexandra Sima   +6 more
doaj   +1 more source

Making Sweat Measurable: Induction, Sampling, and Refreshment in Wearable Biofluid Sensing

Advanced Science, EarlyView.
Wearable sweat sensing relies not only on chemical detection but also on controlled biofluid management. This Review integrates sweat physiology, induction strategies, and microfluidic sampling architectures, demonstrating how flux, transport, and refreshment shape measurement reliability.
Soyoung Shin, Wei Gao
wiley   +1 more source

Gene–Environment Interactions on Body Fat Distribution

, 2019
The prevalence of obesity has been increasing markedly in the U.S. and worldwide in the past decades; and notably, the obese populations are signified by not only the overall elevated adiposity but also particularly harmful accumulation of body fat in ...
Lu Qi, Xiang Li
core   +1 more source

DXA-Derived Body Composition Phenotypes in Men with Chronic Hepatitis C

Sci
Background: Chronic hepatitis C (CHC) is associated with persistent inflammation, metabolic dysfunction, and body composition abnormalities that extend beyond liver disease. However, the coexistence of reduced muscle mass, occult obesity, and altered fat
Mihai Lazar, Cristina Emilia Chitu, Ecaterina Constanta Barbu   +2 more
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source