Results 101 to 110 of about 7,326,298 (287)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Characters Analysis of Genetic Improvement at the Males Population from Romanian Mioritic Shepherd Dog Breed

Scientific Papers Animal Science and Biotechnologies, 2023
The aim of this paper was to analyze, within a group of 26 males from Romanian Mioritic Shepherd Dog breed, 13 characters of genetically improved, characters stipulated in, „Selection sheet and body measurements for Romanian shepherds".
Dorel Dronca, Nicolae Păcală, Lavinia Stef, Ioan Pet, Ioan Bencsik, Marian Bura, Gabi Dumitrescu, Eliza Simiz, Marioara Nicula, Adela Marcu, Liliana Ciochina-Petculescu, Mirela Ahmadi   +11 more
doaj  

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Analysis of Sexual Dimorphism in a Population of Dogs of the Romanian Mioritic Shepherd Dog Breed

Scientific Papers Animal Science and Biotechnologies, 2023
Romanian Mioritic Shepherd Dog was selected from a natural population breed in Carpathian Mountains of Romania. The aim of this study was to analyze the existence and size of sexual dimorphism in a population of 26 males and 23 females of the Mioritic ...
Dorel Dronca, Ioan Peț, Lavinia Ștef, Gabi Dumitrescu, Liliana Ciochină Petculescu, Silvia Pătruică, Mihaela Ivancia, Eliza Simiz, Adela Marcu, Marioara Nicula, Ion Carabă, Silvia Erina, Mirela Ahmadi   +12 more
doaj  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A COMPARISON OF FOALS DEVELOPMENT OF THE LIPIZZANER AND HOLSTEIN BREED [PDF]

Poljoprivreda, 2004
A comparison of the Lipizzaner and Holstein breed offspring shows the growth intensity and the development of body measurements at specific age until turning three. 57 Lipizzaner and 25 Holstein breed foals were included by the research.
Tomo Rastija, Mirjana Baban, Zvonko Antunović, Ivica Mandić, Anđelko Opačak   +4 more
doaj