Results 61 to 70 of about 5,330,662 (291)

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

PROCESSES OF THE GENERALIZED BODY OF KNOWLEDGE IN PROJECT MANAGEMENT

open access: yesРадіоелектронні і комп'ютерні системи, 2019
The present article deals with the development of a generalized body of knowledge in project management. In this paper, a set of processes of this generalized body of knowledge is formed.
И. В. Кононенко, А. Агаи
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

EVOLUTION OF THE GENERALIZED BODY OF KNOWLEDGE ON PROJECT MANAGEMENT

open access: yesВісник Національного технічного університету «ХПÌ». Серія: Стратегічне управління, управління портфелями, програмами та проектами, 2018
An analysis of the literature on the creation and application of hybrid project management methodologies on the basis of fully plan-driven and Agile methodologies is made.
Igor Vladimirovich Kononenko   +1 more
doaj   +1 more source

Ayurvedic Diagnosis - Part 2 [PDF]

open access: yes, 2010
Diagnosis in Ayurveda is based on the ancient conception of ailments in the body generated by three primary kinds of elemental humours: those that accrue from kapha (phlegm), those that are generated by pitta (bile) and, those that result from imbalance ...
Joshi, Himanshu   +3 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

SIGNIFIKANSI KAJIAN METODOLOGI DALAM PENGEMBANGAN BODY OF KNOWLEDGE EKONOMI ISLAM

open access: yesEquilibrium: Jurnal Ekonomi Syariah, 2017
Methodology in science philosophy study is usually discussed in the epistemological discussions which discuss nature, source, concept and theory of knowledge.
Hafas Furqoni
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

EMOTIONAL KNOWLEDGE DYNAMICS [PDF]

open access: yes
The purpose of this paper is to present the place and role of emotional knowledge in the structure of the organizational intellectual capital. Western culture put the emphasis on the rational, cognitive knowledge and ignored almost completely emotional ...
Constantin BRÃTIANU
core  

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