Results 101 to 110 of about 6,207,948 (323)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A Case Series Clinical Trial of a Novel Approach Using Augmented Reality That Inspires Self-body Cognition in Patients With Stroke: Effects on Motor Function and Resting-State Brain Functional Connectivity

Frontiers in Systems Neuroscience, 2019
Barring a few studies, there are not enough established treatments to improve upper limb motor function in patients with severe impairments due to chronic stroke.
Fuminari Kaneko, Fuminari Kaneko, Keiichiro Shindo, Keiichiro Shindo, Masaki Yoneta, Masaki Yoneta, Masaki Yoneta, Megumi Okawada, Megumi Okawada, Megumi Okawada, Kazuto Akaboshi, Kazuto Akaboshi, Kazuto Akaboshi, Meigen Liu   +13 more
doaj   +1 more source

The role of expectation in multisensory body representation – neural evidence [PDF]

, 2017
Sensory events contribute to body ownership, the feeling that the body belongs to me. However, the encoding of sensory events is not only reactive, but also proactive in that our brain generates prediction about forthcoming stimuli.
Ambrosini, Apps, Arizono, Azanon, Ball, Blanke, Blanke, Blanke, Boas, Botvinick, Brigadoi, Brown, Bubic, Burbaud, Carlsson, Cooper, Cope, Corbetta, Costantini, Costantini, Cravo, Cui, Cutini, Duncan, Ede, Ede, Ehrsson, Ehrsson, Ehrsson, Ferri, Ferri, Ferri, Friston, Friston, Friston, Gagnon, Guterstam, Haggard, Halje, Huppert, Ionta, Ionta, Ionta, Kok, Longo, Lopez, Lopez, Lopez, Lunghi, MacKay, Makin, Makin, Mesulam, Mihara, Okada, Okamoto, Olive, Pernet, Perrett, Petersen, Plichta, Rizzolatti, Rousselet, Saenz, Scarpina, Scholkmann, Seltzer, Serino, Shimada, Singh, Singh, Stanton, Thakkar, Tsakiris, Tsakiris, Tsakiris, Wilcox, Worsley, Ye   +78 more
core   +2 more sources

Changing Body Representation Through Full Body Ownership Illusions Might Foster Motor Rehabilitation Outcome in Patients With Stroke

Frontiers in Psychology, 2020
How our brain represents our body through the integration of internal and external sensory information so that we can interact with our surrounding environment has become a matter of interest especially in the field of neurorehabilitation. In this regard,
Marta Matamala-Gomez, Clelia Malighetti, P. Cipresso, E. Pedroli, Olivia Realdon, F. Mantovani, G. Riva   +6 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Gender monstrosity [PDF]

, 2012
Deadgirl (2008) is based around a group of male teens discovering and claiming ownership of a bound female zombie, using her as a sex slave. This narrative premise raises numerous tensions that are particularly amplified by using a zombie as the film’s ...
Jones, Steve
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Relationships Between Personality Features and the Rubber Hand Illusion: An Exploratory Study

Frontiers in Psychology, 2019
The rubber hand illusion paradigm allows investigating human body ownership by inducing an illusion of owning a life-sized fake hand. Despite the wide consensus on the fact that integration of multisensory signals is the main interpretative framework of ...
Dalila Burin, Claudia Pignolo, Francesca Ales, Luciano Giromini, Maria Pyasik, Davide Ghirardello, Alessandro Zennaro, Miriana Angilletta, Laura Castellino, Lorenzo Pia, Lorenzo Pia   +10 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source