Results 111 to 120 of about 185,748 (298)
Start small: A model for tissue-wide planar cell polarity without morphogens.
PLoS Computational BiologyPlanar cell polarity (PCP) is an important patterning mechanism in both vertebrates and invertebrates by which cells coherently polarize along the apical surface of the epithelium.
Abhisha Thayambath, Julio M Belmonte
doaj +1 more source
, 2016 This research has departed from the standard method of flat surface binding of mesh pieces that requires various transformations and restrictions, and instead has attempted to conceive a novel approach that can develop 3D body surfaces into 2D level. Opposed to existing standard pattern flattening method which took utmost reflection of 3D body surface ...
Jinhee Park, Yun-Ja Nam
openaire +2 more sources
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite [PDF]
, 1997 Shortly after their formation, somites of vertebrate embryos differentiate along the dorsoventral axis into sclerotome, myotome and dermomyotome.
Bronner-Fraser, Marianne +2 more
core
Diurnal Patterns of Bovine Body Temperature
Journal of Dairy Science, 1961 Summary Patterns of diurnal body temperature variation were studied in dairy cattle. Classification of 102 continuously recorded daily temperature curves revealed the following features: Sixty-seven per cent showed two distinct daily elevations in temperature, 23% showed only one, 7% were polyphasic, showing three or more sustained rises, and 3% were ...
T.R. Wrenn, Joel Bitman, J.F. Sykes
openaire +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Active Auxetic Heel Support for Achilles Tendon Therapy [PDF]
, 2018 The Achilles tendon, which stretches from the calf to the ankle, can be injured due to repeated daily activities or overstretching. In severe cases a tear in the tendon can prevent athletes from performing in games as well as individuals from completing ...
Hinrichs, Anna +3 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source