Results 91 to 100 of about 3,579,346 (278)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
bowtie-json-schema/bowtie: v2023.08.8
, 2023 What's Changed Feature/dialects path by @harrel56 in https://github.com/bowtie-json-schema/bowtie/pull/379 Change PMD hook and move it to pre-commit config by @OptimumCode in https://github.com/bowtie-json-schema/bowtie/pull/383 Use pnpm in CI and ...
Julian Berman +11 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
bowtie-json-schema/bowtie: v0.79.0
, 2023 What's Changed badges: generant pass pct json files by @santhosh-tekuri in https://github.com/bowtie-json-schema/bowtie/pull/202 badges: dont generate passing badge for unsupported dialects by @santhosh-tekuri in https://github.com/bowtie-json-schema ...
Julian Berman +6 more
core +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
bowtie-json-schema/bowtie: v0.74.1
, 2023 What's Changed Bump serde from 1.0.154 to 1.0.155 in /implementations/rust-jsonschema by @dependabot in https://github.com/bowtie-json-schema/bowtie/pull/168 Bump serde from 1.0.155 to 1.0.156 in /implementations/rust-jsonschema by @dependabot in https:/
Julian Berman +4 more
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Imagining one's own and someone else's body actions: dissociation in anorexia nervosa.
PLoS ONE, 2012 BackgroundPatients with anorexia nervosa (AN) usually report feeling larger than they really are. This body overestimation appears to be related not only to the patient's body image but also to an abnormal representation of the body in action.
Dewi Guardia +7 more
doaj +1 more source