Results 61 to 70 of about 1,176,390 (266)

When Imagining Yourself in Pain, Visual Perspective Matters : The Neural and Behavioral Correlates of Simulated Sensory Experiences [PDF]

open access: yes, 2014
© 2015 Massachusetts Institute of TechnologyPeer reviewedPublisher ...
Christian, Brittany M   +4 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Underpowered samples, false negatives, and unconscious learning [PDF]

open access: yes, 2015
The scientific community has witnessed growing concern about the high rate of false positives and unreliable results within the psychological literature, but the harmful impact of false negatives has been largely ignored. False negatives are particularly
Konstantinidis, Emmanouil   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

The interrelatedness of lexis and morphology in English language learning [PDF]

open access: yesZbornik Radova Filozofskog Fakulteta u Prištini, 2017
The past few decades have seen a sparked interest in the development of vocabulary knowledge in both L1 and L2 learners, resulting in an ever increasing body of research which supports the view that vocabulary and morphology are closely related ...
Danilović-Jeremić Jelena P.
doaj   +1 more source

Does Visual Spatial Awareness Require the Visual Awareness of Space? [PDF]

open access: yes, 2011
Many philosophers have held that it is not possible to experience a spatial object, property, or relation except against the background of an intact awareness of a space that is somehow ‘absolute’. This paper challenges that claim, by analyzing in detail
Schwenkler, Dr. John
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Mindfulness-Based Intervention For Nurses In AIDS Care In China: A Pilot Study. [PDF]

open access: yes, 2019
Background/purpose:Workplace stress among nurses providing care for people living with human immunodeficiency virus is a serious problem in China that may increase rates of job burnout and affect quality of care.
Cai, Yu   +6 more
core  

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

The views of young children in the UK about obesity, body size, shape and weight: a systematic review

open access: yesBMC Public Health, 2011
Background There are high levels of concern about childhood obesity, with obese children being at higher risk of poorer health both in the short and longer terms. Children's attitudes to, and beliefs about, their bodies have also raised concern. Children
Woodman Jenny   +3 more
doaj   +1 more source

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