Results 71 to 80 of about 3,059,466 (305)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Functional Changes Induced by Orexin A and Adiponectin on the Sympathetic/Parasympathetic Balance

Frontiers in Physiology, 2018
Obesity and lifestyle-related diseases are major problems faced by people in developed nations. Although exercise training prevents the progression of diabetes and obesity, the motivation for exercise is generally low in obese animals and humans.
Antonietta Messina, Marcellino Monda, Anna Valenzano, Giovanni Messina, Ines Villano, Fiorenzo Moscatelli, Giuseppe Cibelli, Gabriella Marsala, Rita Polito, Maria Ruberto, Marco Carotenuto, Vincenzo Monda, Andrea Viggiano, Aurora Daniele, Ersilia Nigro   +14 more
doaj   +1 more source

Web-Based Wireless Monitoring System on Patient’s Vital Sign [PDF]

E3S Web of Conferences, 2019
Examination of vital signs such as blood pressure, heart rate, and body temperature is the most basic essential function of the body in determining the health status of the patient. In general, examining vital signs performed by a doctor or nurse uses an
Subito Mery, Alamsyah, Amir Ardi
doaj   +1 more source

What is the nature of RX J0720.4-3125? [PDF]

, 1998
RX J0720.4-3125 has recently been identified as a pulsating soft X-ray source in the ROSAT all-sky survey with a period of 8.391 s. Its spectrum is well characterized by a black-body with a temperature of $8 \times 10^5$ K.
Hernquist, Lars, Heyl, Jeremy S.
core   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Effects of a neuronal nitric oxide synthase inhibitor on lipopolysaccharide-induced fever

Brazilian Journal of Medical and Biological Research, 1999
It has been demonstrated that nitric oxide (NO) has a thermoregulatory action, but very little is known about the mechanisms involved. In the present study we determined the effect of neuronal nitric oxide synthase (nNOS) inhibition on thermoregulation ...
C.A.A. Perotti, M.S. Nogueira, J. Antunes-Rodrigues, E.C. Cárnio   +3 more
doaj   +1 more source

Miniature ingestible telemeter devices to measure deep-body temperature [PDF]

, 1976
A telemetry device comprised of a pill-size ingestible transmitter developed to obtain deep body temperature measurements of a human is described. The device has particular utility in the medical field where deep body temperatures provide an indication ...
Fryer, T. B., Pope, J. M.
core   +1 more source

Effect of Three-body Interaction on Phase Transition of Hot Asymmetric Nuclear Matter

, 2004
The properties and the isospin dependence of the liquid-gas phase transition in hot asymmetric nuclear matter have been investigated within the framework of the finite temperature Brueckner-Hartree-Fock approach extended to include the contribution of a ...
A. Li, Akmal, Alonso, Baldo, Baldo, Baldo, Baldo, Baron, Bertsch, Bombaci, Bombaci, Bonche, Bonche, Brown, Burgio, Catalano, Friedman, Fuchs, Fuchs, Gaitanos, Glendenning, Gobet, Gobet, Grangé, Gupta, Huber, Jaqaman, Jeukenne, Lattimer, Lejeune, Lopez, Machleidt, Marranghello, Matsui, Müller, Prakash, Ray, Schmidt, Serot, Serot, Song, Stock, Strobel, Su, ter Haar, U. Lombardo, W. Zuo, Wiringa, Wiringa, Z.H. Li, Zuo, Zuo   +51 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source