Results 51 to 60 of about 4,888,430 (248)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa +7 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Frontiers in Psychiatry, 2021 Objectives: Although obesity is associated with increased risk for depression in patients with type 2 diabetes mellitus (DM), the relationship between body weight variability (BWV) and depression remains poorly studied.
Ji Hyun An +12 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
PROTEIN CATABOLIC RATE SHOULD BE NORMALIZED BY IDEAL BODY WEIGHT NOT BY POST-DIALYSIS BODY WEIGHT.
Kidney Research and Clinical Practice, 2012 Protein catabolic rate (PCR) is calculated by urea kinetic model thorough the dialysis session and it is recognized as expressing the protein intake in the steady state of dialysis patients.
Ikuto Masakane +4 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
THE CHANGE OF BODY COMPOSITION OF INDIGENOUS RAMS ON DIFFERENT BODY WEIGHT AND FEEDING LEVEL [PDF]
, 2009 The aim of this research was to investigate the influence of body weight and feeding level on the change of body composition of indigenous ram. This research was expected to establish the efficient feeding level to produce high growth rate and meat ...
Setyawan,, A R +4 more
core +1 more source
Sexual dimorphism for juvenile body weight in chickens divergently selected for 8-week body weight
Frontiers in PhysiologyThere is a dearth of literature on the genetics of sexual dimorphism for juvenile body weight in meat-type chickens given its biological and economic relevance. Herein, we report the sexual dimorphism for 4- and 8-week body weights in White Plymouth Rock
Paul B. Siegel, Christa F. Honaker
doaj +1 more source