Results 101 to 110 of about 558,138 (246)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Characteristics of smallholders’ goat production systems and effect of Boer crossbreeding on body measurements of goats in Burundi

Pastoralism, 2020
As part of a national action plan to manage animal genetic resources in Burundi, we characterized smallholders’ goat production systems and assessed the effect of Boer crossbreeding on animal body measures.
Josiane Manirakiza, Gilbert Hatungumukama, Badi Besbes, Johann Detilleux   +3 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Body weight prediction of Brakmas and Bali cattle using body measurements

Malaysian Journal of Animal Science, 2016
In the rural areas facilities for farm animal weighing are often difficult to find and the construction of such facilities is relatively expensive. Therefore a study was conducted with the objective to estimate body weight of Brakmas and Bali cattle using prediction equations of linear body measurements.
Mohd. Hafiz, A.W., Izuan Bahtiar, A.J., Mohamad Hifzan, R., Ashraff, A.L., Ariff, O.M., Faezal Ashraff, A.L.   +5 more
openaire   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Anthropometric measures of obesity as risk indicators for prediabetes. A systematic review and meta-analysis

Diabetes Epidemiology and Management
Introduction: Several previous studies have provided evidence that obesity is a significant risk factor for the increase in prediabetes, but there are discrepancies regarding whether all the classic ways of measuring obesity, the body mass index (BMI ...
Víctor Juan Vera-Ponce, Fiorella E. Zuzunaga-Montoya, Luisa Erika Milagros Vásquez-Romero, Joan A. Loayza-Castro, Cori Raquel Iturregui Paucar, Carmen Inés Gutiérrez De Carrillo, Mario J. Valladares-Garrido, Maritza Placencia Medina   +7 more
doaj   +1 more source

Morphometry and carcass characteristics of goats submitted to grazing in the Caatinga

Revista Brasileira de Zootecnia, 2012
The objective of this study was to evaluate morphometric measures, carcass yields, absolute weights and yields of commercial cuts of carcass of kids with no defined breed. Eighteen castrated male goats, with average weight of 15 kg were used.
Sharleny Braz Lobato Bezerra, Antonia Sherlânea Chaves Véras, Dulciene Karla de Andrade Silva, Marcelo de Andrade Ferreira, Kedes Paulo Pereira, Gladston Rafael de Arruda Santos, André Luiz Rodrigues Magalhães, Omer Cavalcanti de Almeida   +7 more
doaj   +1 more source

Objectively-measured physical activity and body weight in Japanese pre-schoolers

Annals of Human Biology, 2013
The prevalence of thinness has increased among Japanese children.The purpose of this study was to examine the association between physical activity and body mass index (BMI) among Japanese pre-school children.Subjects were 425 4-6-year-old Japanese girls and boys.
Chiaki, Tanaka, Shigeho, Tanaka
openaire   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Composição corporal de pacientes acamados por fraturas do quadril Body composition in bed-ridden adult patients by hip fracture

Acta Ortopédica Brasileira, 2008
As fraturas do quadril são a maior causa de hospitalização da terceira idade, e constituem um considerável encargo econômico e social. A taxa de mortalidade atual após um ano de fratura é acima de 33%, e o risco de morte é maior do quarto ao sexto mês ...
Francisco José Berral, Marcos Moreno, Carlos Javier Berral, Marcos Emilio Kuschnaroff Contreras, Pedro Carpintero   +4 more
doaj   +1 more source