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DEVELOPMENT OF A CRISPR-BASED ANTIVIRAL SYSTEM AGAINST BOHV-1

Cytotherapy, 2021
Background Bovine Herpesvirus type 1 (BoHV-1) infection has no cure and infected animals become lifelong carriers, greatly impacting health and productivity of herds worldwide. The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas (CRISPR associated) tool has been widely explored for the development of antiviral strategies due to ...
VGF Pastre, FRO de Barros
openaire   +1 more source

A triple gene mutant of BoHV-1 administered intranasally is significantly more efficacious than a BoHV-1 glycoprotein E-deleted virus against a virulent BoHV-1 challenge

Vaccine, 2014
Bovine herpesvirus 1 (BoHV-1) causes respiratory infections and abortions in cattle, and is an important component of bovine respiratory disease complex, which causes a considerable economic loss worldwide. Several efforts have been made to produce safer and more effective vaccines.
Shafiqul I, Chowdhury   +4 more
openaire   +2 more sources

A derivative of bovine herpesvirus 1 (BoHV-1) UL3.5 lacking the last forty amino acids inhibits replication of BoHV-1

Archives of Virology, 2004
Bovine herpesvirus 1 (BoHV-1) UL3.5 is a tegument protein that interacts with BoHV-1 alpha-transinducing factor alphaBTIF). In this report, we show that a truncated UL3.5 lacking the last 40 amino acids (C40UL3.5) inhibited replication of BoHV-1. Stable expression of C40UL3.5 in MDBK cells inhibited replication of BoHV-1 300- to 500-fold in plaque ...
N, Lam, G, Letchworth
openaire   +2 more sources

Application experience of polimerase chain reaction for detection BoHV-1 in bull semen

"Veterinary Medicine" Journal, 2023
A. F. Shulyak   +2 more
semanticscholar   +2 more sources

The role of sheep in the epidemiology of Bovine alphaherpesvirus 1 (BoHV-1)

Preventive Veterinary Medicine, 2020
Bovine alphaherpesvirus 1 (BoHV-1) as a cusative agent for some diseases in cattle infects sheep and goat; and it is believed that these animals may be reservoir host for this virus. Thus, BoHV-1 infection in sheep and goat should be considerd when there is a program for control and eradication of this virus in cattle.
Mahdi, Pourmahdi Borujeni   +3 more
openaire   +2 more sources

Characterization of BoHV-1 gE envelope glycoprotein mimotopes obtained by phage display

Veterinary Microbiology, 2004
A phage-displayed peptide library was screened using four mAbs directed against bovine herpesvirus 1 (BoHV-1) gE glycoprotein to identify peptides mimicking this glycoprotein. The selected mimotopes allowed us to characterize the epitopes corresponding to the mAbs as continuous and proteinic and to consider using these peptides in further studies.
D, Lehmann, R, Sodoyer, S, Leterme
openaire   +2 more sources

Seroprevalence and risk factors associated with Bovine Herpervirus Type 1 (BoHV-1) in settlements in the state of São Paulo, Brazil

Medicina Veterinária (UFRPE)
Family farming is an agricultural activity that plays an important socioeconomic role in several Brazilian regions. In the Pontal do Paranapanema region of São Paulo, Brazil, dairy farming is one of the main agricultural activities generating income for ...
M. A. Reyes Alemán   +7 more
semanticscholar   +1 more source

Rapid detection of BoHV-1 genomic DNA by loop-mediated isothermal amplification assay

Journal of Virological Methods, 2014
Bovine herpes virus-1 (BoHV-1) is a serious viral pathogen of domestic and wild cattle. Herein, we report development of a new molecular diagnostic assay for rapid and sensitive detection of BoHV-1 utilizing the loop-mediated isothermal amplification (LAMP) technique.
Alaa A, El-Kholy   +2 more
openaire   +2 more sources

Dynamics of natural bovine herpesvirus-1 (BoHV-1) infection in a dairy herd

Tropical Animal Health and Production, 2007
In this study, natural cycling of BoHV-1 infection was investigated in two groups of dairy cattle containing 2120 head. Group 1 comprised 127 animals and they were monitored for BoHV-1 infection virologically and serologically in six consecutive sampling periods.
Ozkul, A., Gungor, A. Burak
openaire   +3 more sources

The Antiviral Effects of Sodium Phenylbutyrate Against BoHV-1 Infection In Vitro

Letters in Drug Design & Discovery, 2019
Introduction: The alteration of histone acetylation is a known mechanism to regulate gene expression, and thereby affecting various cellular processes. Histone deacetylases (HDACs) are known to regulate histone acetylation by removal of the acetyl group from lysines.
Xinye Chen, Guoqiang Zhu, Liqian Zhu
openaire   +1 more source

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