Results 171 to 180 of about 21,237,171 (206)
A triple gene mutant of BoHV-1 administered intranasally is significantly more efficacious than a BoHV-1 glycoprotein E-deleted virus against a virulent BoHV-1 challenge [PDF]
Vaccine, 2014 Bovine herpesvirus 1 (BoHV-1) causes respiratory infections and abortions in cattle, and is an important component of bovine respiratory disease complex, which causes a considerable economic loss worldwide. Several efforts have been made to produce safer and more effective vaccines.
Shafiqul Chowdhury
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The role of sheep in the epidemiology of Bovine alphaherpesvirus 1 (BoHV-1)
Preventive Veterinary Medicine, 2020Bovine alphaherpesvirus 1 (BoHV-1) as a cusative agent for some diseases in cattle infects sheep and goat; and it is believed that these animals may be reservoir host for this virus. Thus, BoHV-1 infection in sheep and goat should be considerd when there is a program for control and eradication of this virus in cattle.
Mahdi, Pourmahdi Borujeni +3 more
openaire +2 more sources
DEVELOPMENT OF A CRISPR-BASED ANTIVIRAL SYSTEM AGAINST BOHV-1
Cytotherapy, 2021Background Bovine Herpesvirus type 1 (BoHV-1) infection has no cure and infected animals become lifelong carriers, greatly impacting health and productivity of herds worldwide. The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas (CRISPR associated) tool has been widely explored for the development of antiviral strategies due to ...
VGF Pastre, FRO de Barros
openaire +1 more source
Archives of Virology, 2004
Bovine herpesvirus 1 (BoHV-1) UL3.5 is a tegument protein that interacts with BoHV-1 alpha-transinducing factor alphaBTIF). In this report, we show that a truncated UL3.5 lacking the last 40 amino acids (C40UL3.5) inhibited replication of BoHV-1. Stable expression of C40UL3.5 in MDBK cells inhibited replication of BoHV-1 300- to 500-fold in plaque ...
N, Lam, G, Letchworth
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Bovine herpesvirus 1 (BoHV-1) UL3.5 is a tegument protein that interacts with BoHV-1 alpha-transinducing factor alphaBTIF). In this report, we show that a truncated UL3.5 lacking the last 40 amino acids (C40UL3.5) inhibited replication of BoHV-1. Stable expression of C40UL3.5 in MDBK cells inhibited replication of BoHV-1 300- to 500-fold in plaque ...
N, Lam, G, Letchworth
openaire +2 more sources
Enhanced immunogenicity of a BoHV-1 gG-/tk- vaccine
VaccineBovine herpesvirus type 1 (BoHV-1) is a widespread respiratory infection that significantly impacts cattle health worldwide. To address this issue in China, we previously developed a novel double gene-deleted vaccine targeting gG and tk. In this study, we further evaluated the efficacy of this vaccine by challenging vaccinated cattle with a prevalent ...
Yingyu Chen, Guo Aizhen, Guoxing Liu
exaly +3 more sources
Prevalence of exposure to bovine viral diarrhoea virus (BVDV) and bovine herpesvirus-1 (BoHV-1) in Irish dairy herds [PDF]
Research in Veterinary Science, 2015 Bovine viral diarrhoea virus (BVDV) and bovine herpesvirus 1 (BoHV-1) are contagious bovine viral agents. The objectives of this study were to use quarterly bulk milk and ‘spot’ testing of unvaccinated youngstock to establish the national prevalence of ...
R G Sayers, N Byrne, S Arkins
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Characterization of BoHV-1 gE envelope glycoprotein mimotopes obtained by phage display
Veterinary Microbiology, 2004A phage-displayed peptide library was screened using four mAbs directed against bovine herpesvirus 1 (BoHV-1) gE glycoprotein to identify peptides mimicking this glycoprotein. The selected mimotopes allowed us to characterize the epitopes corresponding to the mAbs as continuous and proteinic and to consider using these peptides in further studies.
D, Lehmann, R, Sodoyer, S, Leterme
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BoHV-1 UL3 inhibits RLR signaling response by degrading MAVS
Veterinary MicrobiologyBovine herpesvirus 1 (BoHV-1) infection can lead to host immunosuppression, and its tegument proteins play a critical role in suppressing antiviral immune responses. However, the mechanisms by which BoHV-1 tegument proteins modulate the RLR signaling pathway and influence the replication of bovine RNA viruses remain poorly understood.
Yanan, Xu +3 more
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Biologicals, 2023
Bovine herpes virus-1 (BoHV-1) is responsible for production losses through decreased milk yields, abortions, infertility, and trade restrictions in the bovine population. The disease is endemic in many countries including India. As the virus harbors a unique feature of latency animals once infected with the virus remain sero-positive for lifetime and ...
Sushmita Nautiyal +9 more
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Bovine herpes virus-1 (BoHV-1) is responsible for production losses through decreased milk yields, abortions, infertility, and trade restrictions in the bovine population. The disease is endemic in many countries including India. As the virus harbors a unique feature of latency animals once infected with the virus remain sero-positive for lifetime and ...
Sushmita Nautiyal +9 more
openaire +2 more sources
The Antiviral Effects of Sodium Phenylbutyrate Against BoHV-1 Infection In Vitro
Letters in Drug Design & Discovery, 2019Introduction: The alteration of histone acetylation is a known mechanism to regulate gene expression, and thereby affecting various cellular processes. Histone deacetylases (HDACs) are known to regulate histone acetylation by removal of the acetyl group from lysines.
Xinye Chen, Guoqiang Zhu, Liqian Zhu
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