Results 31 to 40 of about 12,705 (262)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Sliding mode controller with improved AGA for supercharged boiler drum water level control
Zhongguo Jianchuan YanjiuObjectivesIt is difficult to control the drum water level of a supercharged boiler due to the strong load disturbance in the sailing process. In order to ensure the stability of the drum water level, it is necessary to study drum water level control ...
Zhilong DING +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
High Temperature Materials and ProcessesAustenitic heat-resistance steel is widely employed in ultra-supercritical power generation because of its superior performance. This article reports the evaluation of creep damage of a typical Super304H austenitic heat-resistance steel by using the ...
Du Zechen +4 more
doaj +1 more source
Simple Model of Pellet Combustion in Retort Burner
Communications, 2015 Combustion of the solid fuel in the burner is an important issue when discussing the CFD simulation of combustion in automatic boiler. In the present work is employed a simplified method for modeling the fuel bed, which is based on mass and heat balances
Jozef Micieta +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
High Temperature Materials and Processes, 2018 The microstructures and mechanical properties of dissimilar weld joints between T92 and Super 304H steels were investigated. Dissimilar weld joints with four groove angles were constructed using gas tungsten arc welding. The results showed that post-weld
Shuo Wang +3 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2019 The initiation mechanism and its reduction method for combustion driven oscillation of industrial boilers with a center firing gas burner have been investigated experimentally and numerically.
Toshikazu TSUMURA +3 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source