Results 131 to 140 of about 112,725 (304)

Long‐Tea‐CLIP: An Expert‐Level Multimodal AI Framework for Fine‐Grained Green Tea Grading Across Five Sensory Dimensions

Advanced Science, EarlyView.
Long‐Tea‐CLIP (Contrastive Language‐Image Pre‐training) presents a multimodal AI framework that integrates visual, metabolomic, and sensory knowledge to grade green tea across appearance, soup color, aroma, taste, and infused leaf. By combining expert‐guided modeling with CLIP‐supervised learning, the system delivers fine‐grained quality evaluation and
Yanqun Xu, Zhengfang Xue, Qing Luo, Xu Liu, Yongquan Xu, Jing Huang, Xingcai Zhang, Xinyuan Zhang, Zhonghua Liu, Zisheng Luo   +9 more
wiley   +1 more source

Using Problem Frames and projections to analyze requirements for distributed systems [PDF]

, 2004
Subproblems in a problem frames decomposition frequently make use of projections of the complete problem context. One specific use of projec-tions occurs when an eventual implementation will be distributed, in which case a subproblem must interact with ...
Haley, Charles B., Laney, Robin C., Nuseibeh, Bashar   +2 more
core   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Development and validation of detailed building, plant and controller modelling to demonstrate interactive behaviour of system components [PDF]

, 2009
As plant modelling becomes capable of more complexity and detailed resolution, new opportunities arise for the virtual evaluation of discrete plant components such as flow control and energy conversion devices, and controllers.
Cockroft, Jeremy, Kennedy, D., O'Hara, Martin, Samuel, Aizaz Aamir, Strachan, Paul, Tuohy, Paul Gerard   +5 more
core  

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Excavating the iconic: The rediscovery of the Fairbottom Bobs Colliery pumping engine [PDF]

, 2004
Steam engines were one of the first machine-types to attract the attention of antiquarians and later Industrial Archaeologists. From the first Newcomen engine in 1712 to the 20th-century steam turbine, these objects still exert a fascination for ...
Champness, B, Nevell, MD, Roberts, J
core  

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Response to Corner Brook Pulp & Paper Tire Derived Fuel (TDF) Co-Firing Trial Project Proponent: Corner Brook Pulp & Paper Ltd. (Reg. 1539) [PDF]

, 2010
While acknowledging potential economic benefits for Corner Brook Pulp and Paper (CBPP) in using tire-derived fuel (TDF), we remain unconvinced of the net public and environmental health benefits of its use and are concerned with the methodology of the ...
Curtis, Gerard, Ganz, Shoshannah, Hancock, Kim, Kelly, Erin, Levesque, Mario, Novakowski, Nick, Parpia, Osman, Philpott, Tom, Pottle, Susan   +8 more
core  

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source