Advanced Science, EarlyView.This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu +10 more
wiley +1 more source
Determination of Eight Benzene Homologs in Ambient Air and Indoor Air in Residential Areas by Secondary Thermal Desorption-Gas Chromatography. [PDF]
Int J Anal ChemLiu T +6 more
europepmc +1 more source
SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition
Advanced Science, EarlyView.Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo +14 more
wiley +1 more source
Continuous tuning of ejector parameters via zeotropic component migration for optimising high-temperature heat pump. [PDF]
Commun EngLi Z, Liang Y, Zhu Y, Yao S, Yu Z.
europepmc +1 more source
Histone Modification Complex JMJ704‐HDA709 Negatively Regulates Salinity Tolerance in Rice
Advanced Science, EarlyView.This study reveals that the rice histone demethylase JMJ704 interacts with HDA709―a H3K9ac deacetylase characterized herein―to form a chromatin‐modifying complex. Under salt stress, OsWRKY72 recruits this complex through interaction with JMJ704 to target loci, repressing the expression of oxidative stress and salt‐responsive genes via removal of ...
Jing Wang +9 more
wiley +1 more source
Effect of different cooking methods on the sensory, nutritional, and flavor profiles of three <i>Cucurbita moschata</i> and <i>Cucurbita maxima</i> cultivars. [PDF]
Food Chem XXue S +8 more
europepmc +1 more source
Advanced Science, EarlyView.Rare‐earth catalysts regulate lithium–sulfur battery chemistry through f‐orbital–mediated interactions, enabling simultaneous polysulfide adsorption and catalytic conversion on conductive carbon hosts. This synergistic control suppresses the shuttle effect, accelerates redox kinetics, and guides stable Li2S nucleation, providing a mechanistic framework
Fan Wang +5 more
wiley +1 more source
A Novel Pressure-Assisted Induction Melting Technique for Synthesis of Lightweight High-Entropy Alloys: A Concept, Process Development and Hardware Design. [PDF]
Materials (Basel)Newcombe P, Czerwinski F.
europepmc +1 more source
Intermittent Flow Pattern on Two Phase Flow Boiling with Horizontal Microchannel
Intermittent Flow Pattern on Two Phase Flow Boiling with Horizontal MicrochannelIndustrial equipment products had been developed for a small and compact design. Cooling system is also developed to mini heat exchanger with microchannel as main component. The main study is to find the characteristic of flow pattern and heat transfer effect in microchannel.
openaire
CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN
Advanced Science, EarlyView.ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu +13 more
wiley +1 more source