Results 101 to 110 of about 714,094 (293)
Arthritis Care &Research, EarlyView.Objective This study aimed to investigate hand function trajectories over five years in primary hand osteoarthritis (OA). Additionally, determinants of baseline and longitudinal hand function were assessed. Methods A total of 538 patients with both baseline and five‐year study visits were analyzed.
Annemiek V. E. M. Olde Meule +4 more
wiley +1 more source
Prioritizing a Bold Investment in Research for the University of Illinois [PDF]
, 2016 This document provides supplemental information to the proposal “A Bold Investment in Research for the University of Illinois” (v2.0) submitted on April 29, 2016 to the Vice Chancellor for Research (Peter Schiffer), the Chief Information Officer (Mark ...
Towns, John
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Arthritis Care &Research, EarlyView.Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel +6 more
wiley +1 more source
He jishu面对跨学科科学文献的指数级增长与现有检索系统的局限性，本研究基于arXiv平台266万篇论文数据集，创新开发了融合向量语义检索与大型语言模型（Large Language Model，LLM）分析的智能系统。通过构建论文向量数据库实现语义相似性初筛，结合LLM上下文推理优化排序，有效解决了传统关键词搜索的语义鸿沟问题以及LLM的幻觉问题。在核物理领域的应用表明，该系统能精准定位跨学科解决方案，对比特定任务上的关键词检索和向量相似度检索，前10篇文献的查全率从10%跃升到60%，查准率从20%跃升到90%。
庞 龙刚
doaj +1 more source
Clinical, Histologic, and Serological Predictors of Renal Function Loss in Lupus Nephritis
Arthritis Care &Research, EarlyView.Objective Kidney survival is the ultimate goal in lupus nephritis (LN) management, but long‐term predictors remain inadequately studied, requiring long‐term follow‐up. This study aimed to identify baseline and early longitudinal predictors of kidney survival in the Accelerating Medicines Partnership LN longitudinal cohort.
Shangzhu Zhang +21 more
wiley +1 more source
Neighborhood Socioeconomic Status and Short‐Term Functional Outcomes in Systemic Lupus Erythematosus
Arthritis Care &Research, EarlyView.Objective Individuals with systemic lupus erythematosus (SLE) can accumulate functional status (FS) impairment. We evaluated the association between neighborhood socioeconomic disadvantage, as measured by the Area Deprivation Index (ADI), and FS in a national SLE sample.
Baljeet Rai +7 more
wiley +1 more source
低盐胁迫下
Haiyang yu huzhao大菱鲆是我国重要的养殖经济鱼类，随着养殖水域逐渐向滩涂和内陆拓展，亟待研究其低盐适应性机制，进而为培育耐低盐良种提供参考。通过腹腔注射干扰剂dsRNA以及激动剂T091317，以进一步检测下游脂质代谢相关基因的表达以及血清脂代谢产物的变化。研究设置两个盐度梯度(5和30)，每个盐度设置4个处理组(干扰组、激动组、生理盐水组和空白对照组)，实验周期72 h。结果显示：在dsRNA注射后，肝脏中LXRα基因的相对表达量呈现出显著的抑制作用，尤其是在盐度30下；盐度5的肝脏组以及不同盐度的肠道组中 ...
刘 志峰 +8 more
doaj +1 more source
Imaging haemodynamic changes related to seizures: comparison of EEG-based general linear model, independent component analysis of fMRI and intracranial EEG [PDF]
, 2010 Background: Simultaneous EEG-fMRI can reveal haemodynamic changes associated with epileptic activity which may contribute to understanding seizure onset and propagation. Methods: Nine of 83 patients with focal epilepsy undergoing pre-surgical evaluation
Laufs, H. +9 more
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Arthritis Care &Research, EarlyView.Objective This study aimed to describe real‐world trends in preconception and prenatal use of antirheumatic drugs among pregnant individuals with rheumatic diseases in Ontario, Canada. Methods We conducted a time‐series analysis using repeated cross‐sectional data to examine annual patterns of disease‐modifying antirheumatic drug (DMARD) use among ...
Shenthuraan Tharmarajah +6 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) included 585 participants (86 patients with ...
Patrícia Fonseca Estrada +7 more
wiley +1 more source