Results 31 to 40 of about 1,138 (183)

The Risk of Transmission of Genetic Prion Diseases is Greater Than 50%

European Journal of Neurology, Volume 32, Issue 12, December 2025.
This study investigated whether transmission ratio distortion (TRD) occurs in inherited prion diseases, specifically familial Creutzfeldt‐Jakob disease (p.E200K variant) and fatal familial insomnia (p.D178N variant), despite the theoretical 50% autosomal dominant inheritance risk.
Izaro Kortazar‐Zubizarreta, Africa Manero‐Azua, Hasier Eraña, Urko Aguire, Joaquín Castilla, Guiomar Perez de Nanclares   +5 more
wiley   +1 more source

EXPERT OPINION FOR GUIDELINES FOR MANAGEMENT OF PATIENTS WITH COPD

Zdravniški Vestnik, 2002
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Stanislav Šuškovič, Mitja Košnik, Matjaž Fležar, Franc Šifrer, Damjan Eržen, Izidor Kern, Robert Marčun, Katarina Osolnik, Viktorija Tomič, Renato Eržen, Jurij Šorli ml., Jurij Šorli   +11 more
doaj  

The Global Impact of COVID‐19 Control Measures on People With Dementia Living at Home and Their Carers: A Systematic Review of Quantitative and Qualitative Research Across 27 Countries

Brain and Behavior, Volume 15, Issue 11, November 2025.
This graphical abstract summarizes the main findings of our systematic review about the global impacts of COVID‐19 control measures on people with dementia living at home and their carers : they were broadly consistent across regions. Our evidence synthesis highlights the critical need for decision‐makers to account for the needs of PWD and their ...
Yaohua Chen, Tatyana Mollayeva, Rachael Fitzpatrick, Thaisa Tylinski Sant'Ana, Francesca Farina, Dorota Swiatek, Kelli Sopidou, Evelyn Tabilo, Marta Betka, Iracema Leroi, Tomas Leon, Geeske Peeters, the STRAP consortium   +12 more
wiley   +1 more source

Recommendations for the management of patients with chronic obstructive pulmonary disease (COPD) at primary and specialist pulmonary levels in Slovenia

Zdravniški Vestnik, 2017
The purpose of this paper is to implement the guidelines proposed by GOLD in the Slovenian healthcare system, and to describe the cornerstones of the management of this disease.
Sabina Škrgat, Nadja Triller, Mitja Košnik, Tonka Poplas Susič, Davorina Petek, Vlasta Vodopivec Jamšek, Irena Hudoklin, Ana Ogrič Lapajne, Saša Letonja, Jure Šorli, Irma Rozman Sinur, Marjan Koterle, Natalija Edelbaher, Jurij Regvat, Damjan Birtič, Simona Slaček, Mihaela Zidarn, Katja Triller, Matjaž Turel, Katarina Osolnik, Robert Marčun, Matjaž Fležar   +21 more
doaj  

Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power

Acta Ophthalmologica, Volume 103, Issue 7, Page e511-e523, November 2025.
Abstract Purpose The study aims to investigate the effect of pharmacologically reducing parasympathetic activity on ocular and cerebral pulsations, inspired by recent discoveries of a glymphatic‐like system in the eye driven by physiological pulsations.
Seyed Mohsen Ebrahimi, Niko Huotari, Ville Saarela, Marja Honkamo, Lauri Raitamaa, Vesa Korhonen, Johanna Tuunanen, Janne Kananen, Vesa Kiviniemi   +8 more
wiley   +1 more source

Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract BACKGROUND The apolipoprotein E (APOE) gene includes the strongest protective (ε2) and risk (ε4) variants for sporadic Alzheimer's disease (AD), but underlying mechanisms remain unclear. We studied APOE genotype effects on the cerebrospinal fluid (CSF) proteome.
Eleonora M. Vromen, Senne B. Lageman, Johan Gobom, Rik van der Kant, Valerija Dobricic, Lars Bertram, Johannes Streffer, Simon Lovestone, Stephanie J. B. Vos, Mikel Tainta, Yvonne Freund‐Levi, Lutz Frölich, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Frans Verhey, Rik Vandenberghe, Jolien Schaeverbeke, Kaj Blennow, Sven J. van der Lee, Philip Scheltens, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Charlotte E. Teunissen, Henrik Zetterberg, Pieter Jelle Visser, Betty Tijms   +26 more
wiley   +1 more source

PNEUMONIA IN NURSING HOME RESIDENTS

Zdravniški Vestnik, 2002
Background. Pneumonia remains one of the leading causes of morbidity and mortality worldwide, especially in advanced age. Prognosis of the disease depends on premorbid condition and immune competence of the patient, severity of the disease and causative ...
Renato Eržen, Viktorija Tomič, Mitja Košnik, Ema Mušič   +3 more
doaj  

Cortical thickness subtypes in cognitively unimpaired individuals: Differential network and transcriptomic vulnerability to cortical thinning

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION The emergence, stability, and contributing factors of Alzheimer's disease (AD) gray matter subtypes remain unclear. METHODS We analyzed data from 1323 individuals without a diagnosis of dementia (CDR < 1) with T1w‐MRI and amyloid‐PET, including 622 with longitudinal data (3.66 ± 1.78 years).
Luigi Lorenzini, Mario Tranfa, Leonard Pieperhoff, Federico Masserini, Mara ten Kate, Lyduine E. Collij, Giuseppe Pontillo, Emma S. Luckett, Alle Meije Wink, Henk JMM Mutsaerts, Tiago Gil Oliveira, Daniele Altomare, Mercè Boada, Anouk den Braber, Cindy Birck, Christopher Buckley, Gill Farrar, Wiesje van der Flier, Giovanni B. Frisoni, Rossella Gismondi, Juan Domingo Gispert, Bernard J. Hanseeuw, Frank Jessen, Marta Marquié, Anja Mett, Craig Ritchie, Gemma Salvadó, Michael Schöll, Mahnaz Shekari, Andrew W. Stephens, Betty M. Tijms, David Vállez García, Rik Vandenberghe, Pieter Jelle Visser, Luca Roccatagliata, Neil P. Oxtoby, Matteo Pardini, Frederik Barkhof   +37 more
wiley   +1 more source

Patološke spremembe v pljučih pri umrlih bolnikih s covidom-19

Zdravniški Vestnik, 2020
Izhodišče: Bolezen covid-19  povzroča difuzno alveolno okvaro, povezano z visoko stopnjo umrljivosti. Namen analize umrlih bolnikov, okuženih z virusom SARS-CoV-2, je oceniti histopatološke spremembe v pljučih kot glavnem tarčnem organu pri tej okužbi.
Gregor Vlačić, Mile Kovačević, Izidor Kern   +2 more
doaj   +1 more source

Multiple Antibody‐Coated Gold Nanoparticle‐Based ExoAssay for Rapid Isolation of CNS‐Specific Exosomes From Blood

Journal of Neurochemistry, Volume 169, Issue 10, October 2025.
A streamlined nanowire‐based approach (ExoAssay) enabled direct, rapid, and cost‐effective isolation of neuronal extracellular vesicles (EVs) from human plasma using multiple antibody‐coated magnetic nanowires. The isolated EVs were characterized using nanoparticle tracking analysis (NTA), immunoblotting, and transmission electron microscopy (TEM ...
Leticia Camila Fernandez Flores, Neelam Younas, Stefan Goebel, Kathrin Dittmar, Tayyaba Saleem, Abrar Younas, Holger Budde, Tobias J. Legler, Wiebke Möbius, Peter Hermann, Matthias Schmitz, Inga Zerr   +11 more
wiley   +1 more source