Results 91 to 100 of about 4,430,580 (382)

Undirected, Homogeneous C–H Bond Functionalization: Challenges and Opportunities

ACS Central Science, 2016
The functionalization of C–H bonds has created new approaches to preparing organic molecules by enabling new strategic “disconnections” during the planning of a synthetic route.
J. Hartwig, M. Larsen
semanticscholar   +1 more source

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Assessment Of The Casting Position Factor In Reinforced Concrete Elements In View Of Experimental Studies

Archives of Civil Engineering, 2014
The paper presents the results of experimental investigations performed by the authors on the casting position factor. It was proved that at the height of reinforced concrete elements there are different bond conditions.
Dybeł Piotr, Furtak Kazimierz
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Delineating the psychological and behavioural factors of successful weight loss maintenance

Heliyon, 2020
Overweight and obesity present alarming global health problems including detrimental health risks that call for effective interventions. Considerable research has examined behavioural and psychological factors associated with weight loss to advance the ...
Emily Levinge, Peta Stapleton, Debbie Sabot   +2 more
doaj  

Estudo comparativo entre a agressividade superficial obtida na retificação com rebolos de óxido de alumínio e CBN, fabricados com ligantes resinóide e vitrificado The evaluation of the bond resin and vitrified and abrasive grain CBN and alumina influence in the grinding wheel topography characteristics, by the study of the grinding wheel sharpness

Cerâmica, 2011
Este artigo apresenta um estudo da agressividade do rebolo (habilidade de corte). A retificação é um processo de usinagem preciso, o qual é amplamente usado na manufatura de componentes que requerem tolerâncias estreitas e superfícies bem acabadas.
E. C. Bianchi, R. D. Monici, L. D. Neto, A. R. de Aguiar, L. G. Guermandi   +4 more
doaj   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Some Notes On The Tragedy In William Faulkner\u27s The Sound And The Fury [PDF]

, 1958
In lieu of an abstract, below is the essay\u27s first paragraph. Whatever else it may be, and it has run the gamut of critical evaluation, the novel The Sound and the Fury is a tragedy. Whether or not it is a tragedy.
Bond, James
core   +1 more source

Recent advances in the transition metal-catalyzed twofold oxidative C-H bond activation strategy for C-C and C-N bond formation.

Chemical Society Reviews, 2011
The direct functionalization of heterocyclic compounds has emerged as one of the most important topics in the field of metal-catalyzed C-H bond activation due to the fact that products are an important synthetic motif in organic synthesis, the ...
S. Cho, Ji Young Kim, Jaesung Kwak, Sukbok Chang   +3 more
semanticscholar   +1 more source