Results 91 to 100 of about 1,277,787 (315)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Health Services InsightsBackground: Efficient musculoskeletal care is important for health services and society. Surgical conversion rates are a common measure of efficiency, yet normal values and the impact of referrer type are unclear.
Darryn Marks +5 more
doaj +1 more source
Non-Linear Three Dimensional Finite Elements for Composite Concrete Structures
Latin American Journal of Solids and StructuresThe current investigation focused on the development of effective and suitable modelling of reinforced concrete component with and without strengthening. The modelling includes physical and constitutive models. New interface elements have been developed,
O. Kohnehpooshi, M.S. Jaafar
doaj +1 more source
Elias Austin Bond or William Bond Portrait
, 1890 Portrait of a man tentatively identified as Elias Austin Bond of Forest Grove, Oregon; or possibly his brother, William Bond. The identification is based on the existence of this photograph in a run of alumni photos in the Pacific University Archives ...
H. A. Crosley, studio, Forest Grove, Oregon
core
, 2012 A Java subset interpreter was developed for an undergraduate Introduction to Programming course. The interpreter is targeted specifically at complete beginner programmers and addresses aspects relevant or troublesome to novices, such expressions, method ...
Bond Business School, Stocks, Philip
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Geobacter sulfurreducens inner membrane cytochrome transcriptional and phenotypic data
, 2019 The data files include raw data as well as analyzed results for transcriptional analysis of WT G. sulfurreducens and mutant lacking BccR (GSU0598) under fumarate vs iron citrate growth conditions.
Chan, Chi Ho +2 more
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source