Results 61 to 70 of about 198,069 (267)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Evaluation of the shear bond strength of four orthodontic adhesive systems [PDF]

open access: yesAl-Rafidain Dental Journal, 2007
Aims: To evaluate shear bond strength of four types of orthodontic adhesive systems including two–paste composite (Concise), light–cured composite (Transbond), no–mix composite (Alpha–dent) and light–cured glass ionomer cement (Fuji), and to compare ...
Mahmood Kh Ahmed
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Bond strengths of resin-to-metal bonding systems

open access: yesThe Journal of Prosthetic Dentistry, 1997
Resinous materials for the veneers of fixed prostheses commonly require mechanical retention on metal substructures because there is no chemical adhesion. However, mechanical retention does not restrict creation of a marginal gap at the resin-metal interface, which can cause discoloration or detachment of resinous material.
openaire   +3 more sources

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Effect of thermocycling on the micro-tensile bond strength between self-adhesive resin cement and nonphosphate monomer cements on zirconium-oxide ceramics

open access: yesIndian Journal of Dental Research, 2019
Objectives: The objective of the present study is to evaluate the bond strength of: (a) Zirconia blocks (tribochemical treatment and zirconia primer) and resin blocks bonded using self-adhesive resin cement (phosphate monomer cement). (b) Zirconia blocks
S Sathish   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Bond Performance Between Recycled Coarse Aggregate Concrete Reinforced with Polypropylene Fibers and Steel Bars After High-temperature Treatment

open access: yesMedžiagotyra
This paper systematically studies the compressive strength of recycled coarse aggregate concrete with different dosages of polypropylene fibers at high temperatures and the influence of polypropylene fibers on the bond performance between recycled ...
Qihao WANG   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

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